77 Recruiting Studies Using Metformin
Active clinical trials that use this intervention, sourced directly from the NIH registry.
Browse by conditionTrials Using Metformin
Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF)
📍 Cleveland Clinic — Cleveland, Ohio
Atrial Fibrillation
View Study & Checklist ➔Metformin Use in Cardiac Fibrosis in PAI-1 Deficiency
📍 Indiana Hemophilia and Thrombosis Center — Indianapolis, Indiana
Plasminogen Activator Inhibitor-1 Deficiency
View Study & Checklist ➔To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
📍 Massachusetts General Hospital. — Boston, Massachusetts
Breast Cancer
View Study & Checklist ➔Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer
📍 City of Hope Comprehensive Cancer Center — Duarte, California
Atypical Ductal Breast Hyperplasia
View Study & Checklist ➔Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
📍 University of Toledo, Eleanor N. Dana Cancer Center — Toledo, Ohio
Advanced Pancreatic Cancer
View Study & Checklist ➔Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery
📍 City of Hope Medical Center — Duarte, California
Pancreatic Adenocarcinoma
View Study & Checklist ➔Role of Metformin on Muscle Health of Older Adults
📍 University of Utah — Salt Lake City, Utah
Muscle Atrophy
View Study & Checklist ➔Oral Metformin for Treatment of ABCA4 Retinopathy
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
ABCA4 Retinopathy
View Study & Checklist ➔Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
📍 UC San Diego Medical Center - Hillcrest — San Diego, California
Erythroplakia
View Study & Checklist ➔An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer
📍 St. Jude Children's Research Hospital — Memphis, Tennessee
PreDiabetes
View Study & Checklist ➔Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
📍 Massachusetts General Hospital — Boston, Massachusetts
Genetics
View Study & Checklist ➔Combination Gerotherapeutic Interventions for Healthspan Improvement
📍 AgelessRx — Ann Arbor, Michigan
Healthspan Improvement
View Study & Checklist ➔Effect of Metformin, a Drug Used to Treat Diabetes, vs Placebo
📍 UCLA Center for Human Nutrition — Los Angeles, California
NIDDM
View Study & Checklist ➔An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
📍 Clinical Research Facility — Sedona, Arizona
Urothelial Cancer
View Study & Checklist ➔Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients
📍 University of Cincinnati Medical Center — Cincinnati, Ohio
Head and Neck Squamous Cell Carcinoma
View Study & Checklist ➔Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
📍 INSTITUTO DE TERAPÉUTICA EXPERIMENTAL Y CLÍNICA. Centro Universitario de Ciencias de la Salud — Guadalajara, Jalisco
PreDiabetes
View Study & Checklist ➔A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging
📍 Columbia University — New York, New York
Glioblastoma
View Study & Checklist ➔Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma
📍 Brigham and Women's Hospital — Boston, Massachusetts
Monoclonal Gammopathy of Undetermined Significance
View Study & Checklist ➔Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD
📍 UF Health at the University of Florida — Gainesville, Florida
C9orf72 Amyotrophic Lateral Sclerosis (ALS)
View Study & Checklist ➔A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma
📍 Univ of Pittsburgh Medical Center Hillman Cancer Center — Pittsburgh, Pennsylvania
Advanced Melanoma
View Study & Checklist ➔Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
📍 Montreal Neurological Institute - McGill University Health Centre — Montreal, Quebec
Glioblastoma Multiforme
View Study & Checklist ➔Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity
📍 Rita Basu — Birmingham, Alabama
Type 2 Diabetes
View Study & Checklist ➔Glycemic Regulation as Endometriosis Adjunct Treatment
📍 Boston Children's Hospital — Boston, Massachusetts
Pelvic Pain
View Study & Checklist ➔Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis
📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts
Idiopathic Pulmonary Fibrosis
View Study & Checklist ➔Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention
📍 Stanford University — Stanford, California
Prediabetes / Type 2 Diabetes
View Study & Checklist ➔The Effects of Metformin on Morbidity and Mortality in Elderly Patients
📍 Hamilton Health Sciences Centre — Hamilton, Ontario
Burns
View Study & Checklist ➔Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body
📍 Clinical Pharmacology of Miami - Oncology — Miami, Florida
Healthy Participants
View Study & Checklist ➔Metformin and ACLR Muscle Recovery
📍 University of Utah — Salt Lake City, Utah
Atrophy
View Study & Checklist ➔Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
📍 Duke Asthma, Allergy, and Airway Center — Durham, North Carolina
Chronic Obstructive Pulmonary Disease (COPD)
View Study & Checklist ➔Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
📍 Phoenix VA Health Care System, Phoenix, AZ — Phoenix, Arizona
Prediabetic State
View Study & Checklist ➔Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use
📍 University of Alabama at Birmingham — Birmingham, Alabama
Systemic Inflammation
View Study & Checklist ➔Metformin in Pseudomyxoma Peritonei Secondary to Appendiceal Mucinous Neoplasms
📍 Chao Family Comprehensive Cancer Center, University of California, Irvine — Orange, California
Appendiceal Mucinous Neoplasm
View Study & Checklist ➔Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy
📍 Mayo Clinic in Rochester — Rochester, Minnesota
Malignant Brain Neoplasm
View Study & Checklist ➔Limiting AAA With Metformin (LIMIT) Trial
📍 Stanford Hospital and Clinics — Stanford, California
Abdominal Aortic Aneurysm
View Study & Checklist ➔RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer
📍 Massachusetts General Hospital Cancer Center — Boston, Massachusetts
Endometrial Cancer
View Study & Checklist ➔Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
📍 University of Colorado-School of Medicine — Aurora, Colorado
Menopause
View Study & Checklist ➔The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
📍 Indiana University School of Medicine — Indianapolis, Indiana
Type 1 Diabetes
View Study & Checklist ➔Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
📍 UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania
Melanoma
View Study & Checklist ➔Oral Metformin for Treating Melasma in Latin American Women
📍 Administración de Servicios Médicos (ASEM) Clinicas Externas — San Juan, PR
Melasma
View Study & Checklist ➔A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis
📍 The Hospital for Sick Children — Toronto, Ontario
Multiple Sclerosis (MS)
View Study & Checklist ➔MetfOrmin BenefIts Lower Extremities With Intermittent Claudication
📍 VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA — Pittsburgh, Pennsylvania
Intermittent Claudication
View Study & Checklist ➔Metformin and Muscle Recovery
📍 University of Utah — Salt Lake City, Utah
Muscle Atrophy or Weakness
View Study & Checklist ➔Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies
📍 Karmanos Cancer Institute at McLaren Bay Region — Bay City, Michigan
Advanced Solid Tumor
View Study & Checklist ➔Preventing Injured Knees From osteoArthritis: Severity Outcomes
📍 Emory University — Atlanta, Georgia
Osteoarthritis, Knee
View Study & Checklist ➔Metformin IN Asthma for Overweight and Obese Individuals (MINA)
📍 Johns Hopkins University — Baltimore, Maryland
Asthma
View Study & Checklist ➔A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients
📍 James Graham Brown Cancer Center-University of Louisville — Louisville, Kentucky
Melanoma
View Study & Checklist ➔First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
📍 Ellison Clinic at Saint John's — Los Angeles, California
Breast Cancer
View Study & Checklist ➔Precision Dosing of Metformin in Youth With T2D
📍 UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic — Oakland, California
Type 2 Diabetes
View Study & Checklist ➔AMPK-activation by Metformin in FSGS: AMP-FSGS
📍 Yale New Haven Hospital — New Haven, Connecticut
Focal Segmental Glomerulosclerosis
View Study & Checklist ➔A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy
📍 University of Arkansas for Medical Sciences — Little Rock, Arkansas
Castration Sensitive Prostate Cancer
View Study & Checklist ➔Hyperemesis Gravidarum Risk Reduction With Metformin
📍 The Morning Sickness & HG Clinic — Birmingham, Alabama
Hyperemesis Gravidarum
View Study & Checklist ➔Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
📍 University Health System Texas Diabetic Institute — San Antonio, Texas
Type 2 Diabetes (Adult Onset)
View Study & Checklist ➔Prevention of Progression of Prediabetes, Obesity and CV Risk
📍 University of Texas Health Science Center at San Antonio — San Antonio, Texas
Pre-Diabetes
View Study & Checklist ➔Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma
📍 Levine Cancer Institute — Charlotte, North Carolina
Sarcoma Metastatic
View Study & Checklist ➔Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis
📍 Psychosis Intervention Early Recovery Program — St. John's, Newfoundland and Labrador
Psychosis
View Study & Checklist ➔Metformin for Premature Infants With Bronchopulmonary Dysplasia
📍 Children's Wisconsin — Milwaukee, Wisconsin
Bronchopulmonary Dysplasia (BPD)
View Study & Checklist ➔Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
📍 UBMD Neurolgy — Buffalo, New York
Multiple Sclerosis
View Study & Checklist ➔Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
📍 Centre for Addiction and Mental Health — Toronto, Ontario
Intellectual Disability
View Study & Checklist ➔A Study of LY4515100 in Healthy Participants
📍 Fortrea Clinical Research Unit — Dallas, Texas
Healthy
View Study & Checklist ➔Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)
📍 The University of Texas Health Science Center at San Antonio — San Antonio, Texas
Diabetes Mellitus, Type 2
View Study & Checklist ➔Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
📍 University of Iowa — Iowa City, Iowa
Gestational Diabetes
View Study & Checklist ➔Metformin for Fibromyalgia Symptoms (INFORM Trial)
📍 University of Utah — Salt Lake City, Utah
Fibromyalgia Syndrome
View Study & Checklist ➔GDM: Insulin with or Without Metformin?
📍 University of Virginia — Charlottesville, Virginia
Gestational Diabetes
View Study & Checklist ➔Fish Oil, Metformin and Heart Health in PCOS
📍 Human Nutrition Research Unit - Li Ka Shing Health Research Center — Edmonton, Alberta
PCOS
View Study & Checklist ➔Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
📍 University of California-San Diego Medical Center — La Jolla, California
Lactating Women on Select DOI
View Study & Checklist ➔Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation
📍 AgelessRx — Chicago, Illinois
Longevity
View Study & Checklist ➔Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations
📍 Instituto Nacional de Cancerologia — Mexico City,
Non Small Cell Lung Cancer
View Study & Checklist ➔Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma
📍 University of Alabama at Birmingham — Birmingham, Alabama
Posterior Fossa Ependymal Tumor
View Study & Checklist ➔Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance
📍 University of Alberta — Edmonton, Alberta
Obesity, Childhood
View Study & Checklist ➔A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
📍 City of Hope — Duarte, California
Metastatic Breast Cancer
View Study & Checklist ➔MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
📍 Children's Hospital Colorado/University of Colorado Anschutz Medical Campus — Aurora, Colorado
Type 1 Diabetes
View Study & Checklist ➔DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
📍 University of Alabama — Tuscaloosa, Alabama
Gestational Diabetes Mellitus
View Study & Checklist ➔Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients
📍 Colorado Research Center — Aurora, Colorado
Prostate Cancer
View Study & Checklist ➔A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.
📍 HealthOne Denver — Denver, Colorado
TP53 Y220C Mutation
View Study & Checklist ➔Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
📍 Milken Institute School of Public Health - The George Washington University — Washington D.C., District of Columbia
Weight Loss
View Study & Checklist ➔Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
📍 John Hunter Children's Hospital — New Lambton Heights, New South Wales
Medulloblastoma, Childhood
View Study & Checklist ➔Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
📍 University of Kansas Medical Center — Kansas City, Kansas
Cystic Fibrosis-related Diabetes
View Study & Checklist ➔