22 Paid Clinical Research Studies in Orange, California

Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCT

This is a non-blinded, non-randomized dose escalation study of intravenous FBX-101 in which subjects will receive a single infusion of an adeno-associated virus gene therapy produc

📍 Children's Hospital of Orange County (CHOC) — Orange, California

💵 This is a non-blinded, non-randomized dose escalation study of intravenous FBX-101 in which subjects will receive a sing

A Non-significant Risk Clinical Study: Changes in Perfusion After Therapeutic Ultrasound in Patients With PAD

All evaluable subjects will receive VibratoSleeve therapeutic ultrasound (TUS) treatments. The device will be programmed to deliver TUS at a pre-determined level. Three different a

📍 Vascular & Interventional Specialists of Orange County — Orange, California

💵 All evaluable subjects will receive VibratoSleeve therapeutic ultrasound (TUS) treatments.

A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer

The objective of this study is to assess the safety, efficacy, and pharmacokinetics of MRG002, as well as the immunogenicity as defined by the incidence of anti-drug antibody (ADA)

📍 University of California Irvine Chao Family Comprehensive Cancer Center — Orange, California

💵 In Part A, patients will receive MRG002 as a monotherapy at doses of 2.2 or 2.6 mg/kg intravenously (IV) over 60-90 minu

Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections

* The goal of this clinical trial is to learn about medication adherence to difference types of vaginal estrogen in women with low levels of estrogen (for example, post-menopausal

📍 University of California Irvine Medical Center — Orange, California

Gene Transfer Study in Patients With Late Onset Pompe Disease

This is a phase 1/2 open-label, ascending dose, multicenter clinical study to evaluate the safety and efficacy of AT845 in adult (aged ≥ 18 years) subjects, ambulatory or nonambula

📍 University of California Irvine, Department of Neurology — Orange, California

💵 Subjects will receive a single dose of AT845 delivered via intravenous (IV) infusion.

Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis

This phase I trial studies the side effects of isatuximab and to see how well it works in treating patients with high risk immunoglobulin light chain amyloidosis (AL amyloidosis).

📍 University of California — Orange, California

💵 All patients will receive Isatuximab (weekly x 4 then every other week) plus dexamethasone 4 mg PO/IV days weekly.

Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ

The purpose of the study is to estimate the ability of mirtazapine to reduce depression, nausea, and vomiting, and maintain weight in depressed glioma patients undergoing Temozolom

📍 UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California

💵 * Histologically confirmed diagnosis of glioma * No prior treatment with temozolomide TMZ * Patient will receive temozol

Investigation of DEXA-C Anterior Cervical Interbody System

FDA Cleared interbody product for the cervical spine, designed to match a patients DEXA scan for increase in fusion rate.

📍 UCI Center for Clinical Research — Orange, California

Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)

A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects wit

📍 Children's Hospital Orange County — Orange, California

💵 Of that 78, 52 participants will receive active treatment, and a total of 26 participants will receive placebo.

Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)

The purpose of this study is to determine if the use of image-guided, endovascular therapy (EVT) is an effective strategy with which to reduce Post Thrombotic Syndrome (PTS) diseas

📍 St. Joseph's Vascular Institute — Orange, California

💵 All participants will receive standard PTS therapy.

Patient Satisfaction and Cosmetic Outcomes in Adhesive Strip Versus Suture Repair for Simple Facial Lacerations

There are a variety of techniques utilized to close lacerations, including but not limited to, traditional sutures, staples, adhesive strips, and skin glue. While closing open woun

📍 University of California Irvine — Orange, California

Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle coun

📍 University of California Irvine Medical Center — Orange, California

💵 All subjects will receive diet and lifestyle counseling throughout the study.

Risk-ADAPTed Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation

This is a prospective, single-arm, phase II study. Patients will be treated with an allogeneic stem cell transplantation (AHSCT) using fludarabine, melphalan and total body irradia

📍 Chao Family Comprehensive Cancer Center, University of California Irvine — Orange, California

💵 Eligible patients will receive an allogeneic stem cell transplantation using a combination of fludarabine, melphalan and

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (Sa

📍 Orange County Heart Institute — Orange, California

💵 Study Design Participant Enrollment and Setup Participants will receive the Peerbridge Cor® wearable, with data collec

Cardiac Structure and Function in MPS

The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS). The investigators are looking at certain s

📍 Children'S Hospital of Orange County — Orange, California

A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease

The main purpose of this study is to look at how efgartigimod affects thyroid function in adults with Graves' Disease (GD). The study will also check whether efgartigimod is safe a

📍 Diabetes Associates Medical Group — Orange, California

💵 During the part A and part B treatment periods, participants will receive efgartigimod PH20 SC via Prefilled Syringe (PF

Acute Partial Thickness Burn Study Comparing Transforming Powder Dressing to Standard of Care Dressing

This study is being performed to assess the effectiveness of Altrazeal(R) Transforming Powder Dressing (TPD) in patients with partial thickness burns compared to the current standa

📍 University of California-Irvine — Orange, California

L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma

Open-label, single-arm, multicenter study in patients with locally advanced, histologically confirmed Cutaneous Squamous Cell Carcinoma (LacSCC) amenable to intratumoral injection,

📍 UC Irvine Health- Chao Family Comprehensive Cancer Center — Orange, California

💵 The patients will receive multiple intratumoral administrations of combined L19IL2 and L19TNF to all injectable cutaneou

Latinx Children and Surgery

Over 60 million persons in the United States (US) identify themselves as Latinx and 25.6% are children under the age of 16. Surgical disparities for adults and children have been

📍 Children's Hospital of Orange County — Orange, California

The Actuate-CBC Study

The study team will use implementation science to accelerate the uptake of teleconsultationfor burn patients by 1) examining the relationships between clinician perceptions of acce

📍 UCI Health Regional Burn Center — Orange, California

A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)

In this PIERRE-PK study, researchers will learn how the body processes nusinersen when it is given through the ThecaFlex DRx™ System, compared to when nusinersen is given by lumbar

📍 Children's Hospital of Orange County — Orange, California

💵 * Participants will receive a dose of nusinersen by the ThecaFlex DRx system, as part of the PIERRE study.

TrialNet Pathway to Prevention of T1D

Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes

📍 Childrens Hospital of Orange County — Orange, California