25 Paid Clinical Research Studies in Indianapolis, Indiana

Pembrolizumab Plus Olaparib in LA-HNSCC

The purpose of this research study is to evaluate the effectiveness of using a combination of pembrolizumab and olaparib when given before and after standard chemoradiation therapy

📍 Indiana University Simon Comprehensive Cancer Center — Indianapolis, Indiana

💵 In the induction phase, participants will receive one infusion of pembrolizumab and will take olaparib tablets for a tot

Digital Single Session Intervention for Youth Mental Health

The aim of this study is to test the effectiveness of a single-session, digital intervention teaching the principle of practicing the opposite, when administered to youths on the w

📍 Riley Child Psychiatry and Behavioral Sciences Clinic — Indianapolis, Indiana

A Nasal Treatment for COVID-19

The goal of this study is to test an investigational new inhaled medication called Optate.

📍 Riley Hospital for Children — Indianapolis, Indiana

In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization

The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults. Pa

📍 Oral Health Research Institute — Indianapolis, Indiana

Naxitamab for High-Risk Neuroblastoma Patients With Primary Refractory Disease or Incomplete Response to Salvage Treatment in Bone and/or Bone Marrow

Children and adults diagnosed with high-risk neuroblastoma patients with primary refractory disease or incomplete response to salvage treatment in bone and/or bone marrow will be t

📍 Riley Hospital for Children — Indianapolis, Indiana

💵 Naxitamab, also known as hu3F8 is a humanised monoclonal antibody targeting GD2 Each patient will receive treatment for

ABVN Phase 2-Studying the Effect of Stimulation on the Auricular Branch of the Vagal Nerve

The purpose of this study is to find out if we can gain access to the vagus nerve which is largely an internal nerve that controls stomach function. We hope to gain access to the i

📍 Indiana University — Indianapolis, Indiana

Effect of Stimulation on the Vagus Nerve

The vagus nerve is a largely-internal nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the e

📍 Indiana University Hosptial — Indianapolis, Indiana

Magnetic Resonance Imaging of the Brain and Stomach in Healthy Volunteers and Gastroparesis

The study is to lay the groundwork for non invasive imaging of the GI tract and the brain gut interaction

📍 Indiana University School of Medicine — Indianapolis, Indiana

Pregnancy at a Time That Is Happy and Healthy for You

In an effort reduce maternal and infant mortality and health disparities overall, PATH4YOU (Pregnancy At a Time that's Healthy and Happy for You) will be implemented starting in Ma

📍 Indiana University Hospital — Indianapolis, Indiana

Integrative Medicine in Pain Management in Sickle Cell Disease

The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.

📍 Indiana University School of Medicine — Indianapolis, Indiana

💵 During the study visits: 1) Subjects will be randomized to 10 sessions with either traditional acupuncture (very fine ac

Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer

The purpose of this research study is to test the safety of Niraparib and dostarlimab as a combination treatment and see what effects (good and bad) this combination treatment has

📍 Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis, Indiana

💵 If found eligible, the patient will receive treatment with Niraparib daily and dostarlimab by vein every three weeks for

Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)

This is a phase 2 study of gemcitabine, cisplatin, zimberelimab (AB122) and quemliclustat (AB680) in subjects with untreated advanced biliary tract cancers (BTC). The study will in

📍 Indiana University Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis, Indiana

💵 Participants will receive 4 cycles of combination therapy as described.

Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease

This is a prospective pilot study to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coro

📍 IU Health Methodist Hospital — Indianapolis, Indiana

Automated, Assistive, Non-Contact Sleep Quality Monitor for Individuals With Alzheimer's Disease

This study seeks to evaluate the utility and efficacy of the Non-Contact Sleep Quality Monitor System when used to monitor the sleep quality of individuals living in long-term care

📍 Indiana University School of Medicine — Indianapolis, Indiana

Impact of Standardization on Outcomes Following Cervical Ripening

The primary purpose of this study is to determine if vaginal delivery rate is impacted by the use of standardized methods of cervical ripening. Additional outcomes will be evaluate

📍 Sidney & Lois Eskenazi Hospital — Indianapolis, Indiana

Finding Immune Nascent Type 1 Diabetes

The goal of this clinical trial is to understand how many individuals who previously participated in the Indiana Biobank will return a type 1 diabetes home screening kit based upon

📍 Indiana University School of Medicine — Indianapolis, Indiana

Needle Free Assessment of Myocardial Oxygenation in Healthy Subjects

This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of

📍 IU Health Methodist Hospital — Indianapolis, Indiana

Study of Resmetirom in Children and Adolescents With MASH

This study will evaluate the safety, pharmacokinetics (how the body absorbs, distributes, metabolizes, and eliminates the drug), and pharmacodynamics (how the drug affects the body

📍 Riley Hospital for Children at IU Health — Indianapolis, Indiana

💵 Participants will receive oral resmetirom once daily for approximately 14 days at one of several dose levels.

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to impro

📍 Riley Children's Hospital- Clinics / Labor and Delivery Unit — Indianapolis, Indiana

Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery

The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the

📍 Indiana University — Indianapolis, Indiana

SPARK Healthy Sleep

SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems. About 1 in 4 college s

📍 Indiana University — Indianapolis, Indiana

Unilateral M1 Anodal tDCS to Enhance Learning in a Gross Movement Videogame Task

Virtual reality as a gaming method is being used more regularly due to its immersive environments and total body playability. A few studies have used VR paired with brain stimulati

📍 National Institute for Fitness and Sport — Indianapolis, Indiana

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics. The study population wi

📍 Indiana University — Indianapolis, Indiana

💵 Patients will receive PO or IV antibiotics for 6 weeks at discharge from the hospitalization to treat the infected unhea

The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture

This application addresses the Peer Reviewed Medical Research Program Investigator-Initiated Research Award FY21 W81XWH-22-CPMRP-IIRA area of Chronic Pain Management Research Progr

📍 Indiana University School of Medicine — Indianapolis, Indiana

GI Neuromuscular Pathology Prospective Registry

In this research study, biopsy samples will be collected to provide more insight into the underlying cause of the motility disorders, help direct further investigation into the cau

📍 Indiana University Hosptial — Indianapolis, Indiana