33 Paid Clinical Research Studies in Iowa City, Iowa

Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial

The purpose of this single arm open label phase 1b clinical study is to see what effect zoledronic acid has on tumors in patients with resectable any grade chondrosarcoma prior to

📍 University of Iowa Hospitals and Clinics — Iowa City, Iowa

💵 Prior to surgery, subjects will receive 1 standard dose of IV zoledronic acid given over 15 minutes.

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

This clinical trial evaluates adding high-dose ascorbate (vitamin C) to standard of care treatment of glioblastoma multiforme (a type of brain tumor) in adults. All subjects will r

📍 Holden Comprehensive Cancer Center — Iowa City, Iowa

💵 All subjects will receive high-dose ascorbate in addition to the standard treatment.

Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema

This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of

📍 University of Iowa — Iowa City, Iowa

Cerebellar TDCS for SRPCS Treatment

This study is investigating the immediate and long-term effects of bilateral cerebellar transcranial direct current stimulation on cognition, balance, and symptom severity in peopl

📍 Thorsten of Rudroff — Iowa City, Iowa

Autoimmune Intervention Mastery Course Study

The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS), clinically i

📍 Univeristy of Iowa — Iowa City, Iowa

💵 Patients will receive access to the online program and 7 group support videos (released one per week or 7 weeks total).

Target Engagement of Terazosin in Healthy Adults

The purpose of the study is to assess the target engagement of Terazosin (TZ) in a single cohort of 6 healthy adult participants. During the study participants will undergo PET/CT

📍 University of Iowa Hospitals and Clinics — Iowa City, Iowa

A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma

This clinical trial evaluates adding ferumoxytol and pharamcologic ascorbate (vitamin C) to standard of care treatment of glioblastoma multiforme (a type of brain tumor) in adults.

📍 Department of Radiation Oncology at University of Iowa — Iowa City, Iowa

💵 All subjects will receive ferumoxytol and pharmacologic ascorbate in addition to the standard treatment.

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

This clinical trial evaluates adding high-dose ascorbate (vitamin C) to a standard therapy for non-small cell lung cancer. The standard therapy is radiation therapy combined with c

📍 Holden Comprehensive Cancer Cener — Iowa City, Iowa

💵 All subjects will receive high-dose ascorbate in addition to the standard therapy.

Pharmacokinetics of Transdermal Metronidazole

This is a crossover pharmacokinetic clinical study in healthy volunteers to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin

📍 University of Iowa — Iowa City, Iowa

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with

📍 University of Iowa — Iowa City, Iowa

Improving Antibiotic Use for ARIs in Urgent Care Clinics

Many clinicians prescribe antibiotics for patients with acute respiratory infections even when antibiotics will not benefit the patient because the infection is due to a virus. To

📍 University of Iowa Hospitals and Clinics — Iowa City, Iowa

Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD

Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity which can progress to deadly complications like end-stage liver disease and hepatocellular carcinoma.

📍 University of Iowa Health Care — Iowa City, Iowa

💵 Participants will receive Optifast® replacement meals at no cost.

Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis

The study is a Phase 3, open-label, randomized controlled trial of gene therapy intervention by subretinal administration of AAV2-hRPE65v2 (voretigene neparvovec-rzyl). At least tw

📍 University of Iowa — Iowa City, Iowa

💵 This study will deliver AAV2-hRPE65v2 vector (voretigene neparvovec-rzyl) to at least sixteen intervention group subject

RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

This a Phase 3, prospective, open-label, multicenter study of \[15-O\]-H2O injection for PET imaging of subjects with suspected CAD. Approximately 182 evaluable participants with s

📍 University of Iowa — Iowa City, Iowa

💵 All participants will receive two doses of \[15-O\]-H2O as part of a single PET imaging session (one dose at rest and on

MR and Inflammation After Preeclampsia

The purpose of this investigation is to examine the role of inappropriate mineralocorticoid receptor activation in endothelial dysfunction and vascular inflammation in otherwise he

📍 University of Iowa — Iowa City, Iowa

Efficacy of Diet on Quality of Life in Multiple Sclerosis

The overarching goal of this project is to critically evaluate the efficacy of incorporating dietary guidance within multiple sclerosis (MS) care for improving long-term quality of

📍 Univeristy of Iowa — Iowa City, Iowa

A Stepped Care Approach to Treating Tobacco Use in Rural Veterans

Tobacco use remains prevalent among Veterans. Although effective smoking cessation interventions exist, long-term term quit rates remain sub-optimal. The project will investigate t

📍 Iowa City VA Healthcare System — Iowa City, Iowa

💵 All participants will receive the investigators' tailored, six session smoking cessation intervention developed over a s

Povidone Iodine for Caries Prevention

The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to

📍 University of Iowa College of Dentistry — Iowa City, Iowa

💵 Subjects will receive reminders ahead of a scheduled home application of PI via text message or communication method of

Dimensional Changes: Randomized Clinical Trial

The goal of this clinical trial is to evaluate the dimensional changes in the short and long-term in patients with thin gum tissues who have gum grafts placed on either denuded bon

📍 University of Iowa College of Dentistry and Dental Clinics — Iowa City, Iowa

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter

📍 University of Iowa Hospital and Clinics — Iowa City, Iowa

Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia

Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this

📍 University of Iowa — Iowa City, Iowa

Sex Differences in the Vascular Effects of E-cigarette Use

The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction

📍 University of Iowa — Iowa City, Iowa

Concurrent TMS-fMRI

The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI)

📍 University of Iowa Carver College of Medicine — Iowa City, Iowa

Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility

The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how th

📍 The University of Iowa — Iowa City, Iowa

Stimulant Effects on Disruptive Behavior

The goal of this study is to determine the effects of stimulant medication on disruptive behavior, function, preference and choice; however, it is primarily methodological and will

📍 University of Iowa Hospitals and Clinics — Iowa City, Iowa

Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC

The goal of this clinical trial is to learn whether a combination of two chemotherapy drugs, Gemcitabine and Docetaxel, can treat high-grade non-muscle-invasive bladder cancer (HG-

📍 University of Iowa — Iowa City, Iowa

💵 Participants will receive intravesical Gemcitabine immediately followed by Docetaxel once weekly for 6 weeks (induction

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions,

📍 Univeristy of Iowa — Iowa City, Iowa

💵 Participants will receive an individual link to their baseline assessments via REDCap.

ACEs, SIRT1, and Premature Vascular Aging in Humans

Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of

📍 Integrative Laboratory of Applied Physiology and Lifestyle Medicine — Iowa City, Iowa

Cerebellar Stimulation and Cognitive Control

The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder,

📍 University of Iowa — Iowa City, Iowa

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Gre

📍 Integrative Laboratory of Applied Physiology and Lifestyle Medicine — Iowa City, Iowa

Cell Free DNA in Cardiac Sarcoidosis

Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dy

📍 University of Iowa — Iowa City, Iowa

Oxytocin and Fetal Heart Rate Changes

The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the in

📍 University of Iowa Hospitals and Clinics — Iowa City, Iowa

Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff

The primary purpose of this research study is to determine if forces within carbon fiber custom dynamic orthoses (CDOs) can be reliability assessed using Loadpad and Loadsol force

📍 University of Iowa — Iowa City, Iowa