20 Paid Clinical Research Studies in Louisville, Kentucky

Neoadjuvant PD-1 Blockade in Patients with Stage IIB/C Melanoma

The main purpose of this study is to determine the rate of positive sentinel lymph nodes (i.e. the closest draining lymph node(s) to the primary melanoma site) and to test whether

📍 University of Louisville — Louisville, Kentucky

💵 Post-operatively, subjects will receive up to 1 year of adjuvant pembrolizumab 200 mg every 3 weeks.

Non-Invasive Spinal Cord Stimulation After Injury

The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combina

📍 Frazier Rehabilitation and Neuroscience Institute — Louisville, Kentucky

A Single Center, Open-Label Study to Evaluate the Ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to Detect Tear Film Stability Utilizing Miebo®

A study to investigate the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo®

📍 Butchertown Clinical Trials — Louisville, Kentucky

Study of Eftilagimod Alfa (Efti) in Combination With Pembrolizumab and Chemotherapy Versus Placebo in Combination With Pembrolizumab and Chemotherapy in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) (TACTI-004)

The purpose of this study is to compare eftilagimod alfa (efti) in combination with pembrolizumab and chemotherapy versus placebo in combination with pembrolizumab and chemotherapy

📍 Norton Cancer Institute - Audubon — Louisville, Kentucky

💵 Participants will receive either efti plus standard treatment (pembrolizumab and platinum doublet chemotherapy) or place

Pomegranate Dietary Supplements in AUD and ALD

The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.

📍 University of Louisville — Louisville, Kentucky

Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study

The goal of this study is to test the efficacy and feasibility of Colesevelam administration (50% of the recommended dose) to reduce serum PFAS concentration in the Veteran populat

📍 Robley Rex VA Medical Center — Louisville, Kentucky

Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia

Chronic pain affecting the pelvic and urogenital area is a major clinical problem and can have a profound impact on quality of life and health care costs. Pelvic pain arising from

📍 University of Louisville Division of Urogynecology and Reconstructive Pelvic Surgery — Louisville, Kentucky

Esophageal and Gastric Registry and Biorepository

The evaluation of the foregut, the esophagus and stomach, has come a long way over the past two decades, and continues to experience exciting discoveries in the clinical evaluation

📍 Norton Healthcare — Louisville, Kentucky

Betadine vs Sterile Water for Periurethral Preparation

The purpose of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water (water that has been treated to remove bacteria an

📍 UofL Physicians - Urogynecology Springs Urogynecology Office — Louisville, Kentucky

Encouraging a Plant Based Diet in an Underserved Urban Population

The investigator's goal is to promote a plant-based diet amongst the underserved urban population of Louisville with the help of educational aids and the provision of affordable re

📍 University of Louisville Ambulatory Internal Medicine Resident Clinic — Louisville, Kentucky

Peppermint Oil for the Treatment of Interstitial Cystitis / Bladder Pain Syndrome

The purpose of this study is to assess the use of peppermint oil as a treatment for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).

📍 Springs Medical Center — Louisville, Kentucky

Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention

This randomized control trial study among Pre-exposure prophylactic users (PrEP) aims to learn and determine the efficacy of Screening, brief intervention, and referral to treatmen

📍 University of Louisville — Louisville, Kentucky

Reactions to Distress (RED) In Louisville, KY Study

The goal of this study is to understand whether race-related stress can impact the way people direct their attention and what interventions may be helpful for attention.

📍 Davidson Hall — Louisville, Kentucky

Health, Environment and Action in Louisville (HEAL) Green Heart Louisville Project

The purpose of this study is to examine how the environment and neighborhood characteristics affects the health of the area residents. The study will help determine how changing ne

📍 University of Louisville — Louisville, Kentucky

Effects of 5HTP on the Injured Human Spinal Cord

This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and

📍 University of Louisville — Louisville, Kentucky

💵 In a placebo-controlled, randomized crossover design, participants will receive i) 50 mg 5HTP combined with 50 mg carbid

Intermediate Visual Space Perception

The ability to judge the locations of various objects from oneself during self-motion in the intermediate distance range (\~2-25m) is crucial for successful performance of activiti

📍 University of Louisville — Louisville, Kentucky

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

This is a first-in-human (FIH), open-label, multiple-site, dose escalation study which will evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of increasi

📍 Norton Cancer Institute PARENT — Louisville, Kentucky

💵 Participants may receive investigational medicinal product (IMP) for up to 2 years or until they experience disease prog

Supporting Resilience Among Re-entered Seniors

The first goal (Aim 1) of this clinical trial is to learn about specific strengths, challenges, and desired areas of knowledge and skill-building among older adults who re-entered

📍 New Legacy Reentry — Louisville, Kentucky

Combination Therapy for Recurrent Ovarian Cancer

The proposed study "combination therapy with liposomal doxorubicin and withaferin A (Ashwagandha, ASWD) in recurrent ovarian cancer" is focused to determine the feasibility and max

📍 UofL Health Brown Cancer Center — Louisville, Kentucky

💵 Adequate organ function within 14 days prior to first WFA/ASWD dose or liposomal doxorubicin whichever occurs first, inc

Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients

Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender

📍 University of Louisville Health — Louisville, Kentucky