15 Paid Clinical Research Studies in Cambridge, Massachusetts

Effects of Altered Auditory Feedback on Speech Fluency

The purpose of the study is to use altered auditory vocal feedback to increase fluency in people who stutter and to examine changes in this effect over the course of a one month pe

📍 Massachusetts Institute of Technology — Cambridge, Massachusetts

💵 Step 2: Participants will receive an additional form via Redcap through which they can input information about what devi

Investigating the Effects of Social Stress on Brain Imaging

The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences in brain activation i

📍 Massachusetts Institute of Technology — Cambridge, Massachusetts

OpenEvidence Safety and Comparative Efficacy of Four LLM's in Clinical Practice

OpenEvidence is an online tool that aggregates and synthesizes data from peer-reviewed medical studies, then producing a response to a user's questions using generative AI. While i

📍 Cambridge Health Alliance — Cambridge, Massachusetts

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

Breathing brief, moderate bouts of low oxygen trigger (low oxygen therapy, LOT) spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new expe

📍 Spaulding Rehabilitation Hospital — Cambridge, Massachusetts

💵 After 14 days of istradefylline treatment, the participants will receive 2 weeks (4 sessions/week) of LOT prior to 45min

Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans

There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression. A new technology has emerged in the last de

📍 Massachusetts Institute of Technology - McGovern Institute for Brain Research — Cambridge, Massachusetts

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA). We are doing the resea

📍 Spaulding Cambridge Hospital — Cambridge, Massachusetts

💵 During the treatment session, participants will receive either ESWT or sham ESWT with measures of oxidative stress obtai

Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. The inve

📍 Massachusetts Institute of Technology — Cambridge, Massachusetts

💵 Half of the participants will receive sham treatment, meaning they will use the investigators' device but the light and

Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise

The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions t

📍 Spaulding Rehabilitation Hospital — Cambridge, Massachusetts

Home Use Study of Targeted Mechanical Stimulation for Tremor Relief

Subjects will receive prototype devices to be used for participation. The study comprises three phases: 1. Alpha phase: Two remote study visits and an in-home period to gather dev

📍 Encora Therapeutics — Cambridge, Massachusetts

💵 Subjects will receive prototype devices to be used for participation.

Gamma Frequency Stimulation in Individuals With Down Syndrome

Down Syndrome (DS) is characterized by an additional copy of chromosome 21, which also increases risk of Alzheimer's Disease (AD). The investigators' lab found a non-invasive way t

📍 Massachusetts Institute of Technology — Cambridge, Massachusetts

Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks

The purpose of this study is to evaluate the performance of a powered ankle prosthesis capable of bidirectional control via neural recording and cutaneous stimulation, during free-

📍 MIT Media Lab — Cambridge, Massachusetts

Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote mea

📍 Spaulding Rehabilitation Hospital — Cambridge, Massachusetts

Pre-exposure Prophylaxis (PrEP) for Health

This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among a

📍 AIDS Action — Cambridge, Massachusetts

💵 After eligibility confirmation and baseline assessments, participants will be randomized to one of two study arms: 1) St

Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)

Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in

📍 MIT — Cambridge, Massachusetts

Study of Wearable Interventions for Improving Mobility of Individuals With Knee Osteoarthritis

Knee osteoarthritis (OA) affects an estimated 654 million people over age 40 world-wide. In the United States, approximately 16% of adults over the age of 40 have knee OA. Pain, ac

📍 MIT Media Lab — Cambridge, Massachusetts