21 Paid Clinical Research Studies in Worcester, Massachusetts

The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication

This study will focus on people with claudication from peripheral arterial disease. The investigators are researching whether a multicomponent therapeutic can increase the producti

📍 UMASS Memorial Healthcare - University Campus — Worcester, Massachusetts

💵 All subjects will receive 2 different drug doses of the Kuvan the first 45 days they will receive 10 mg/kg/day.

FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry

Aim 1. Establish a national registry of diverse patients of orthopedic surgeons representing all regions of the country and varied hospital and surgeon practice settings (e.g., urb

📍 University of Massachusetts Memorial Health Center; Arthritis and Total Joint Center — Worcester, Massachusetts

💵 Patients will receive an invitation to complete the 6 month survey either on the computer at home or on paper.

Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft.

The objectives of this longitudinal study are to assess and measure fusion status (fused or not fused) and rate of bony fusion using NanoBone® Synthetic Bone Graft in patients requ

📍 UMass Memorial Health Care — Worcester, Massachusetts

💵 Each subject will serve as their own control during this study, as patients will receive the Nanobone graft on the right

Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease

The MELODY Trial: Modulating Early Life Microbiome through Dietary Intervention in Crohn's Disease, will test whether a non-invasive dietary intervention during pregnancy can impro

📍 University of Massachusetts Medical School — Worcester, Massachusetts

💵 Subjects will receive nutritional counseling and training, and compliance to dietary recommendations will be recorded.

Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation

The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune syst

📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts

ActivityChoice: Implementing Clinic-Based Physical Activity Program Choices for Cancer Survivors

Cardiovascular disease, the number one leading cause of death in the United States, is highly prevalent in cancer survivors. Physical activity can reduce risk, and referrals to pro

📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts

FMT in Uncomplicated Diverticulitis

Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C. diff infection usually aris

📍 UMASS Memorial Medical Center — Worcester, Massachusetts

Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients

Discrepancies exist among aortic stenosis severity classification, patient symptom burden, and - in some cases - even survival. The new Stress Aortic Valve Index (SAVI) metric corr

📍 UMass Medical Memorial Center — Worcester, Massachusetts

💵 Furthermore patients will receive non-invasive testing with an exercise echocardiogram and computed tomography (CT) scan

Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts

Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery

📍 UMassMemorial Health Care — Worcester, Massachusetts

💵 All participants will receive lifestyle strategy materials on fatigue mitigation to improve performance.

Social Media and Risk-reduction Training for Preterm Infant Care Practices

SMART Preemie is a cluster randomized trial that will investigate the effectiveness of NICU-based and post-discharge interventions to improve adherence to safe sleep practices amon

📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts

Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes

This project tests a training strategy to help rural jails start or increase their use of medications to treat opioid use disorder (MOUD - methadone, buprenorphine, naltrexone). St

📍 UMass Chan Medical School — Worcester, Massachusetts

Impact of a Virtual Reality-based Mindfulness Program on Clinician Wellness

Burnout shares symptoms with anxiety and depression. While there is no single intervention for burnout, there are validated interventions (which are amenable to virtual reality (VR

📍 UMassMemorial Health Care — Worcester, Massachusetts

Neighborhood Connect

The study is evaluating the effectiveness of an implementation strategy called Neighborhood Connect, which is designed to support residents' engagement in activities that improve t

📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts

ShotBlocker During Intramuscular Injection Randomized Control Trial

The objective of this trial is to evaluate the effect of Bionix ShotBlocker on pain of injection of the first Hepatitis B vaccine in healthy newborns. ShotBlocker is a pain reducin

📍 UMass Memorial Medical Center- Memorial Campus — Worcester, Massachusetts

ARISe at UMass Chan

The goal is to identify the most impactful strategies for capturing attention and enhancing effectiveness of vaccine promotion messages. This will be done using an online survey th

📍 University of Massachusetts Chan Medical School — Worcester, Massachusetts

Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

The purpose of the study is to quantitatively characterize the flow in the pelvic venous structures using 2D and 4D flow MRI with the objective of establishing physiologic and path

📍 University of Massachusetts — Worcester, Massachusetts

Retropubic Hydrodissection and Trocar-induced Bladder Perforation During Retropubic Midurethral Slings

Retropubic midurethral slings are a common and effective treatment for stress urine incontinence. The trocar that is attached to the mesh material can hit the bladder which is call

📍 University of Massachusetts Memorial Medical Center — Worcester, Massachusetts

Ear-Seizure Detection (EarSD) Study

The proposed study is an investigator-initiated study that aims to measure the accuracy of a wearable seizure detection and prediction device (Ear-Seizure Detection Device (EarSD))

📍 Ummmc-Memorial Campus — Worcester, Massachusetts

The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma

The goal of this clinical trial is to learn if education about additional task lighting, enhanced contrast, enlarged print instructions, smart apps and organizational strategies wi

📍 MCPHS 10 Lincoln Square — Worcester, Massachusetts

Social Needs Screening and Chronic Diseases Study (WE CARE)

The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in

📍 UMass Memorial Medical Center - Hahnemann Campus — Worcester, Massachusetts

Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A

This Study will comprehensively evaluate a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs

📍 UMass Memorial Health — Worcester, Massachusetts

💵 All subjects will receive follow-up phone calls for 12 months after enrollment at weeks 6, 12, 24, 36, and 52.