42 Paid Clinical Research Studies in Columbia, Missouri

Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants

The purpose of the study is to investigate the effects of pulse consumption versus no pulse consumption on the gut microbiome, meal satiety, and short-chain fatty acid metabolomics

📍 University of Missouri — Columbia, Missouri

This Study Consists of Two Study Parts Conducted Under a Single IRB. Part I: Short Term ApoE-dependent Cerebral Blood Flow Response to Sirolimus in Cognitively Normal Adults Part II: Short Term ApoE-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal Adults

This study consists of two study parts (Part I and Part II) conducted under a single IRB approval. Individuals that participated in Part I of the study were invited to participate

📍 University of Missouri-Columbia — Columbia, Missouri

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

📍 University of Missouri — Columbia, Missouri

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular fun

📍 University of Missouri — Columbia, Missouri

Growth Hormone Resistance of Beta-cells

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people

📍 University of Missouri School of Medicine — Columbia, Missouri

Effects of Sirolimus on Asymptomatic ApoE4 Carriers

Alzheimer's disease is a devastating neurodegenerative disease characterized by accumulation of clumps (also called plaques) and bundles of fibers (also called tangles) in the brai

📍 University of Missouri — Columbia, Missouri

NeuroControl of Nicotine Dependence

The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to deter

📍 Health Neuroscience Center — Columbia, Missouri

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, whi

📍 University of Missouri-Columbia — Columbia, Missouri

Sleep as a Mechanism of Change in Alcohol Use

This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.

📍 University of Missouri-Columbia — Columbia, Missouri

Development of Novel Psychological Assessment Tools and Anxiety Intervention for Phenylketonuria

While previous PKU intervention research has largely focused on pharmacological treatment of elevated Phe levels, the adaptation of evidence-based psychosocial therapy holds promis

📍 University of Missouri — Columbia, Missouri

💵 Participants will receive the 10-week Show Me First program for treatment of anxiety and depression.

Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozy

📍 University of Missouri-Columbia — Columbia, Missouri

High Protein Diet and Atherosclerosis

Atherosclerosis is the underlying cause of the majority of cardiovascular diseases, including myocardial infarction and strokes, and results in tremendous morbidity and mortality.

📍 University of Missouri School of Medicine — Columbia, Missouri

Smoking Cessation Behavioral Treatment Study

The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Beha

📍 University of Missouri - Columbia — Columbia, Missouri

Empagliflozin Reversal of Arterial StiffnEss in Aging

Randomized placebo-controlled clinical trial in a cohort of males (n=40) and females (n=40), 60-80 years of age, with the hypothesis that SGLT2 inhibition with empagliflozin (10mg/

📍 University of Missouri — Columbia, Missouri

Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

Rare genetic neurodevelopmental disorders, such as Syt-1 or Baker Gordon Syndrome (BAGOS) arise from mutations in genes essential for brain development and function, often disrupti

📍 University of Missouri - Columbia — Columbia, Missouri

An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction

This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic

📍 University of Missouri - Columbia — Columbia, Missouri

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic funct

📍 University of Missouri School of Medicine — Columbia, Missouri

Early Neurovascular Adaptations in Aging Women

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

📍 University of Missouri-Columbia — Columbia, Missouri

Implementation Supports for Improving Identification and Delivery of School-based Mental Health Supports for Middle Schools Students

This study will assess how different types of training and support influence the way that school staff understand, and respond to, the mental and behavioral health needs of middle

📍 University of Missouri — Columbia, Missouri

Dietary Fiber Effects on the Microbiome and Satiety

Strong evidence supports the association between high fiber (HiFi) diets (e.g. legumes, nuts, vegetables) and a reduced risk for chronic conditions such as cardiovascular disease (

📍 University of Missouri-Columbia — Columbia, Missouri

Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people

📍 University of Missouri School of Medicine — Columbia, Missouri

Growth Hormone Resistance of Beta-cells A

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people

📍 University of Missouri School of Medicine — Columbia, Missouri

Animal and Plant Proteins and Glucose Metabolism

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-r

📍 University of Missouri School of Medicine — Columbia, Missouri

Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, whi

📍 University of Missouri School of Medicine — Columbia, Missouri

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathe

📍 University of Missouri — Columbia, Missouri

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging

📍 University of Missouri — Columbia, Missouri

Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers

Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Circulatin

📍 Ellis Fischel Cancer Center, University of Missouri — Columbia, Missouri

Remote Sensing for ADRD-Specific Activities Identification in Older Adults

The investigators aim to use smart-home sensors and artificial intelligence (AI) to monitor and detect Alzheimer's Disease and Related Dementias (ADRD)-specific daily activities am

📍 University of Missouri — Columbia, Missouri

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic funct

📍 University of Missouri School of Medicine — Columbia, Missouri

Compass 3: A Novel Transition Program to Reduce Disability After Stroke

This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke. Half of the participants w

📍 University of Missouri — Columbia, Missouri

💵 Half of the participants will receive a stroke education program while the other half will receive an environmental modi

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.

📍 University of Missouri-Columbia — Columbia, Missouri

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, earl

📍 Harry S Truman Veterans Memorial Hospital — Columbia, Missouri

Lipoprotein Kinetics in T1D

The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigato

📍 University of Missouri School of Medicine — Columbia, Missouri

CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Paste

📍 University of Missouri — Columbia, Missouri

Impact of Sleep Restriction on Blood Pressure Reactivity

The purpose of the research study is to examine the effects of shortened sleep on blood pressure.

📍 University of Missouri — Columbia, Missouri

Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass

Open pilon fractures are challenging problems to manage. Infection rates vary from 6-30% and metaphyseal nonunion varies from 7-20%. The current recommendation for the management o

📍 University of Missouri - Columbia — Columbia, Missouri

💵 All enrolled participants will receive the Aeridyan matrix.

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

The goal of this clinical trial is to learn whether showering with surgical drain tubes in place after first stage breast reconstruction causes increased risk of infection. The mai

📍 University of Missouri — Columbia, Missouri

Web-based Cognitive Behavioral Treatment for Insomnia in Dementia Caregivers

Over the next 30 years, more than 10 million persons living with dementia in the United States will receive care at home from an unpaid and untrained family caregiver. At home care

📍 University of Missouri — Columbia, Missouri

Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity

The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on art

📍 Harry S. Truman Memorial, Columbia, MO — Columbia, Missouri

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adu

📍 NextGen Precision Health Building, Clinical and Translational Science Unit — Columbia, Missouri

Brain Blood Flow and Lactate in Non-obese and Obese Subjects

Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF ca

📍 University of Missouri — Columbia, Missouri

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

📍 University of Missouri-Columbia — Columbia, Missouri