37 Paid Clinical Research Studies in Chapel Hill, North Carolina

REAL-Fam Feasibility Study for Youth Diabetes Management

The goal of this clinical trial is to learn if the REAL-Fam occupational therapy intervention is feasible to study in a larger-scale randomized controlled trial. It will also seek

📍 The University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Preventing Type 2 Diabetes in Black Emergent Adult

Black Americans are disproportionately affected by diabetes, with nearly double the rates of type 2 diabetes mellitus (T2DM), compared to non-Hispanic White adults. Though numerous

📍 UNC-Chapel Hill — Chapel Hill, North Carolina

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian

This is single center, open-label phase 1 dose escalation trial that uses modified 3+3 design to identify a recommended phase 2 dose (RP2D) of CAR.B7-H3 T cell product. An expansio

📍 Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina

💵 In part 2 of the study, the subjects will receive the CAR.B7-H3 T cells.

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

The body has different ways of fighting infection and disease. No single way is perfect for fighting cancer. This research study combines two different ways of fighting disease: an

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

💵 Subjects will receive either ATLCAR.CD30.CCR4 or the ATLCAR.CD30.CCR4 product in combination with an ATL product encodin

Human Autologous Lung Stem Cell Transplant for Idiopathic Pulmonary Fibrosis

Purpose: To demonstrate the safety and efficacy of autologous Lung Spheroid Stem Cells (LSCs) administered by intravenous infusion in patients with idiopathic pulmonary fibrosis P

📍 University of North Carolina as Chapel Hill — Chapel Hill, North Carolina

💵 All patients will receive standard of care for their IPF.

Hispanic Community Health Study / Study of Latinos

The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a multi-center epidemiologic study in Hispanic/Latino populations to determine the role of acculturation in the

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Pilot of Continuous Glucose Monitor-Augmented Food Is Medicine

This study is designed to test the feasibility and preliminary efficacy of a continuous glucose monitor (CGM)-augmented food is medicine (FIM) intervention for adults with type 2 d

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

💵 Following the 12-week intervention, all participants will receive both FIM intervention and wear real-time CGM for a 4-w

Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL

The body has different ways of fighting infection and disease. No single way is effective at fighting cancer. This research study combines two different ways of fighting disease: a

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

💵 Lymphodepleting Regimen Subjects will receive a lymphodepleting regimen of fludarabine 25 mg/m2/day administered IV ove

Dupilumab for Eosinophilic Esophagitis With Severe Strictures

The purpose of this research study is to determine how well an FDA-approved drug, dupilumab, works to treat patients with severe strictures and active Eosinophilic Esophagitis (EoE

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

💵 If eligible and enrolled into the study, participants will receive weekly subcutaneous (under the skin) injections of du

Impact of Financial Incentives

This trial will look at the impact of clinic-level financial incentives to improve provider communication and increase HPV vaccine uptake. Some clinics will receive communication t

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Water From Bottles to Establish Strong Teeth

The waterBEST study is a proof-of-concept, randomized, double-masked, placebo controlled, parallel group study evaluating dental caries-preventive effects of fluoridated bottled wa

📍 Division of Pediatric and Public Health, UNC Adams School of Dentistry — Chapel Hill, North Carolina

Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program

The goal of this study is to learn if integrating a chatbot into an existing 12-week smartphone-delivered behavioral weight loss program is feasible and effective for weight loss a

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

This research study combines 2 different ways of fighting disease: antibodies and T cells. Both antibodies and T cells have been used to treat patients with cancers, and both have

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

💵 These subjects will receive one of two assigned dose levels of rimiducid with their second standard of care treatment.

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease:

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

💵 Eligibility Criteria Prior to Lymphodepletion for Second Infusion (Optional) Note: Subjects may receive a second infusio

mPATH-Cloud for Colorectal Cancer Screening

This study assesses the effectiveness of colorectal cancer (CRC) screening intervention, mobile Patient Technology for Health (mPATH™-Cloud), compared to usual care among subjects

📍 Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

PRO-VISION: Patient Reported Outcomes-Based Monitoring of VEGF-Inhibitor Side Effects in ONcology

The purpose of this study is to investigate how collecting information about treatment-related side effects directly from patients can help manage the side effects associated with

📍 Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina

💵 Participants will receive a follow-up phone call or message from the team when participants have new or worsening sympto

The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma

The goal of this study is to learn whether children, adolescents, and young adults with newly diagnosed high-grade osteosarcoma can be safely discharged from the hospital at slight

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

💵 Participants will receive standard chemotherapy, meet study-defined discharge criteria, be monitored for side effects, a

Treating Binge Eating and Obesity Digitally in Women

More than 30% of Black women with obesity binge eat. Binge eating may increase the risk for the development of metabolic syndrome and binge-eating-disorder (BED), which is associat

📍 UNC-Chapel Hill — Chapel Hill, North Carolina

Developing and Strengthening Cannabis Warnings: Warning Message Testing

The purpose of this activity is to identify promising cannabis warning messages from different themes. Participants will be adults who live in the United States, including both peo

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

A Targeted Electronic Health Approach to Reduce Fear of Recurrence in Breast Cancer Survivors (FoRtitude)

The goal of this study is to determine if the intervention or if general information about being a breast cancer survivor can help Breast Cancer Survivors reduce their fear of recu

📍 UNC Chapel Hill School of Medicine Public Health — Chapel Hill, North Carolina

Teen Vulnerability to Irritability: Brain and Estrogen Changes

Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of

📍 Biomedical Research Imaging Center (BRIC) at UNC — Chapel Hill, North Carolina

The PharmFIT Study

This study will conduct a randomized controlled trial to assess the impact of a pharmacy-based FIT intervention, Pharmacy-based FIT (PharmFIT), on colorectal cancer screening (CRC)

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

Evaluation of Impact of AI Assistance on Workload Associated w Preparation of Rare Tumor Case Repts

The goal of this study is to explore cognitive burden perceptions among physicians in relation to case report writing. Furthermore, this study evaluates the use of artificial intel

📍 Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina

Revumenib, Azacitidine, and VENetoclax in Newly Diagnosed KMT2A-Rearranged AML

This study is testing a new treatment combination called RAVEN, which includes revumenib, azacitidine, and venetoclax, in patients who are newly diagnosed with a specific type of a

📍 Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina

💵 Induction Phase: Patients will receive treatment for up to 3 cycles.

Characterization of Doxycycline Pharmacokinetics and Adherence

The purpose of this study is to evaluate the effect of body changes on doxycycline concentrations for different dosing schedules. This study will involve a single dose phase and a

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Optimization of Dietary Adherence in a Mobile Weight Loss Intervention

The goal of this study is to test multiple individual treatment components added to a 6-month standard mobile behavioral weight loss program that are intended to help participants

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

💵 All participants will receive the Core 6-month behavioral weight loss program, which is a comprehensive intervention tha

Mast Cell Treatment in Post-tick Bite Illness (PTBI)

This is a Phase II double-blinded study to assess the safety, tolerability, and feasibility of the mast cell stabilizing medications ketotifen and cromolyn compared to participants

📍 University of North Carolina — Chapel Hill, North Carolina

Daily Upgrade Trial

This study evaluates the acute and chronic effects of an essential amino acid supplement (Daily Upgrade EAA+) on metabolomics, amino acid kinetics, metabolic rate, body composition

📍 Applied Physiology Laboratory — Chapel Hill, North Carolina

Personalized Environment and Genes Study

Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20%

📍 University of North Carolina — Chapel Hill, North Carolina

Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' resp

📍 Biomedical Research Imaging Center Marsico Hall (UNC) — Chapel Hill, North Carolina

Healthy Living Anson Study

The goal of this randomized delayed control intervention research study is to see if participants who receive education and healthy prepared meals improve the quality of their diet

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modif

📍 Mary Ellen Jones — Chapel Hill, North Carolina

Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

This prospective study will test artificial intelligence (AI) and machine learning (ML) decision support tools. This tool is designed to help doctors, physicists and other staff du

📍 University of North Carolina at Chapel Hill, Department of Radiation Oncology — Chapel Hill, North Carolina

Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging

This is a 4-arm, single-center study involving 40 participants. Ten healthy volunteers will be enrolled for system imaging optimization, and thirty (30) patients with previously id

📍 The University of North Carolina — Chapel Hill, North Carolina

Accountability for Care Through Undoing Racism & Equity for Moms

This project-also known as "Accountability for Care through Undoing Racism \& Equity for Moms" or ACURE4Moms-aims to reduce Black-White maternal health disparities using multi-leve

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

Comparing a Workplace Resilience and a Physical Activity Intervention on Early Childhood Educators Well-being

The goal of this 15-month cluster clinical trial is to compare a resilience and stress management program to a physical activity program for early childhood education (ECE) staff o

📍 UNC Center for Health Promotion and Disease Prevention — Chapel Hill, North Carolina

Caring for the Carer

The purpose of the present study is to investigate the acceptability and feasibility of implementing a novel, Cognitive Behavioral Therapy (CBT) intervention to caregivers and supp

📍 University of North Carolina at Chapel Hill — Chapel Hill, North Carolina

💵 Participants will receive the individual therapy intervention once per week or bi-weekly, for 20 sessions, over the cour