18 Paid Clinical Research Studies in Charlotte, North Carolina

Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast Cancer

The goal of this phase II study is to test the combination of trilaciclib, pembrolizumab, gemcitabine, and carboplatin in locally advanced unresectable or metastatic triple-negativ

📍 Levine Cancer Institute — Charlotte, North Carolina

💵 Eligible participants will receive the study treatment until disease progression, unacceptable toxicity, or withdrawal f

REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss

The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive pro

📍 Atrium Health - Levine Cancer Institute — Charlotte, North Carolina

A Study of LP-118 In Combination With Ponatinib, Dexamethasone And Blinatumomab For Adults With Newly-Diagnosed, BCR::ABL1-Positive Acute Lymphoblastic Leukemia (ALL)

The purpose of this research study is to see if a drug called LP-118 is safe and effective for treating adults with Philadelphia chromosome-positive (Ph+) B cell acute lymphoblasti

📍 Atrium Health Levine Cancer — Charlotte, North Carolina

💵 All participants will receive standard of care treatment for newly diagnosed Ph+ ALL consisting of the FDA approved drug

Tisotumab Vedotin in Squamous Cell Carcinoma of the Vulva

This is an open-label, single arm, phase 2 study designed to evaluate the efficacy of tisotumab vedotin in participants with recurrent or metastatic squamous cell carcinoma of the

📍 Atrium Health Levine Cancer Center — Charlotte, North Carolina

💵 Patients will receive tisotumab vedotin every 3 weeks (21 days plus or minus 3 days).

Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients

Pharmacogenomic (PGx) testing involves analyzing variants of genes associated with drug metabolism, transport and medication targets. PGx testing uses an individual's genetic facto

📍 Levine Childrens Hospital Pediatric Cancer and Blood Disorders — Charlotte, North Carolina

💵 Apart from the availability and use of PGx test results to guide pharmacotherapy, participants will receive standard of

Evaluation of the Pathobiology of CALR-mutated MPN Cells

The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.

📍 Atrium Health Levine Cancer — Charlotte, North Carolina

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

This is a Phase II clinical trial testing the use of two antigen-directed therapies, inotuzumab and blinatumomab, as part of induction therapy for children and young adults with ne

📍 Novant Health Presbyterian Hemby Children's Hospital — Charlotte, North Carolina

💵 * These patients may receive no more than 2 weeks of post-induction therapy and should be transitioned to SJALL23H post-

Pre-malignant States to Hematologic Malignancies in Firefighters

The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases

📍 Levine Cancer Institute — Charlotte, North Carolina

A Single-arm, Phase II Clinical Trial of ASPIRin to prEvent Venous Thromboembolism in Patients With Advanced Germ Cell Tumors Receiving Chemotherapy

The purpose of this study is to the 6-month Venous Thromboembolism (VTE)-free rate in participants with advanced germ cell cancer at high risk of VTE who are receiving standard of

📍 Atrium Health Wake Forest Baptist Comprehensive Cancer Center — Charlotte, North Carolina

💵 +1 point for testicular/germ cell cancer (All patients will receive +1 for their testicular/germ cell cancer diagnosis.

LATe Cerclage in High-risk Pregnancies (LATCH)

The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (

📍 Atrium Health Carolinas Medical Center — Charlotte, North Carolina

Daoist Zhanzhuang and Human Flourishing

This project investigates the impact of Daoist Zhanzhuang (sometimes spelled as Chan Chuang) on human flourishing, and explores the physiological, psychological, and spiritual mech

📍 University of North Carolina at Charlotte — Charlotte, North Carolina

Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US

This study has 3 aims. Aim 1: Identify social determinants of cardiometabolic health and determine facilitators and modifiable barriers in achieving treatment goals. Aim 2: Assess

📍 Duke University - Charlotte Study Sites — Charlotte, North Carolina

MiREA-AC for Reducing Problematic Alcohol and Marijuana Use in College Students

The goal of this STTR Phase I funded study is to address the urgent need for an effective primary prevention approach to the problem of heavy episodic drinking and cannabis misuse

📍 University of North Carolina, Charlotte — Charlotte, North Carolina

💵 The students will be instructed to use the app for two weeks, during which the participants will receive constant person

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

This will be a global Phase IV, open-label, randomised study to evaluate the safety and tolerability of acalabrutinib (monotherapy, 100 mg orally \[po\], twice daily \[bd\]) compar

📍 Research Site — Charlotte, North Carolina

💵 Randomised controlled study: Treatment phase: Patients will receive treatment with either acalabrutinib 100 mg po tabl

A Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18 Years of Age With Generalized Myasthenia Gravis

The purpose of this study is to measure the pharmacokinetics (PK), pharmacodynamics (PD), safety, tolerability, and immunogenicity of efgartigimod PH20 SC in pediatric participants

📍 Carolinas HealthCare System Neurosciences Institute - Neurology — Charlotte, North Carolina

💵 Participants will receive injections of efgartigimod PH20 SC and will be monitored for safety until the end of the study

The SKyRoCKeT Study

The SKyRoCKeT Study (Surface-Knit and Reformulate CADENCE-Kids for Translation) will recruit a sex- and age-balanced sample of 360 young people 6-20 years of age to develop an inte

📍 University of North Carolina at Charlotte — Charlotte, North Carolina

Lung B.A.S.E.S. 4 Life Mobile Low-dose Computed Tomography (LDCT) Screening: Ages 40-54

Low-dose CT Screening has been shown in two large trials in the United States (NLST) and Europe (NELSON) to increase overall survival in subjects 55 years of age and older with a s

📍 Levine Cancer Institute — Charlotte, North Carolina

CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study

The purpose of this study is to identify multiple myeloma in the precancerous MGUS stage in order to reduce the risk of delayed diagnosis of multiple myeloma, decrease morbidity re

📍 Atrium Health Levine Cancer — Charlotte, North Carolina