25 Paid Clinical Research Studies in Durham, North Carolina

Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab

Subjects with resectable melanoma will receive neoadjuvant nivolumab followed by surgical resection. Post-operatively, subjects will receive open-label treatment with up to 1 year

📍 Duke Cancer Institute — Durham, North Carolina

💵 Post-operatively, subjects will receive open-label treatment with up to 1 year of adjuvant nivolumab or ipilimumab plus

Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

A parallel-group randomized pilot trial at a single institution (Duke University) on the effect of postoperative hyperbaric oxygen therapy on wound healing in patients with soft ti

📍 Duke University — Durham, North Carolina

💵 All participants will receive pre-operative radiation treatment per standard of care and will undergo surgical excision

Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations

This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retinitis pigmentosa caused by RPGR m

📍 Duke University — Durham, North Carolina

💵 Each participant will receive the study agent by subretinal injection in one eye on a single occasion.

Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer

This is a window-of-opportunity study which will evaluate the safety and feasibility of single-dose neoadjuvant Hepatic Artery (HA) chemotherapy (FUDR/oxaliplatin) in patients with

📍 Duke University Health System — Durham, North Carolina

💵 On Day 2 (±1 day), patients will receive the interventional treatment, which is neoadjuvant HA chemotherapy.

Multisite Prevention of Conduct Problems (Fast Track)

The primary aim of this project is to evaluate the effects of a comprehensive intervention to prevent severe and chronic conduct problems in a sample of children selected as high-r

📍 Duke University — Durham, North Carolina

Pancoronavirus Vaccine Study in Healthy Adults

Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory s

📍 Duke University Health System — Durham, North Carolina

DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Patients with newly diagnosed glioblastoma will be consented following tumor resection then undergo leukapheresis for harvest of peripheral blood leukocytes for generation of dendr

📍 Duke University Medical Center — Durham, North Carolina

💵 All patients will receive up to a total of 10 DC vaccines called pp65 CMV dendritic cells (DC).

ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM

This is a phase 1b study of P30-linked EphA2, CMV pp65, and survivin vaccination (collectively called the P30-EPS vaccine) in HLA-A\*0201 positive patients with a newly diagnosed,

📍 The Preston Robert Tisch Brain Tumor Center at Duke University — Durham, North Carolina

💵 Patients will receive seven P30 linked-EphA2, -CMV pp65, and -survivin (P30-EPS) peptide vaccines over two phases.

PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma

The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma. Patients with histological

📍 Duke University Medical Center — Durham, North Carolina

💵 Once a patient has enrolled onto this study, prior therapy will be terminated and patients will receive temozolomide 200

Baby Steps III: Testing a Clinician and Patient Intervention to Promote Smoking Cessation Among Pregnant Women

The investigators propose to conduct a combined intervention that pairs SMS smoking cessation messages for patients with individualized training for OB clinicians to improve quit r

📍 Durham OB — Durham, North Carolina

Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)

The purpose of this feasibility study is to compare the impact of Spinal cord stimulation \[SCS\] for Spinal Cord Injury (SCI) pain and rehabilitation. SCS, also known as Epidural

📍 Duke University Health Systems — Durham, North Carolina

💵 Under the direction of the study physician, the patient may receive a variety of treatments, such as medications and var

Gulf War Era Cohort and Biorepository

The Gulf War Era Cohort and Biorepository pilot project collected epidemiological, survey, clinical, and environmental exposure data from Veterans who served during the 1990-1991 G

📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina

Botensilimab and Balstilimab Optimization in Colorectal Cancer

This is a single-arm, interventional, pilot clinical trial. Fifteen evaluable patients will have tumor-informed ctDNA testing at baseline and start botensilimab and balstilimab tre

📍 Duke University — Durham, North Carolina

💵 5.2 Treatment Period During the Treatment Period, subjects will receive botensilimab every 6 weeks for up to 4 doses an

Boosting Exercise Adherence in Knee Osteoarthritis

This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise amon

📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina

💵 During the initiation phase (first 3 months of PT care), patients will receive tools and activities to address outcome e

Mitigating Racial Disparities in Shared Decision Making in the Intensive Care Unit

This is a non randomized pilot trial aimed to: Test the feasibility of an intervention to support intensive care unit clinicians in conducting shared decision making conversations

📍 Duke University Medical Center — Durham, North Carolina

Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF

The study is a pilot analysis using a decision on the risk and benefits of oral anticoagulation for stroke reduction for patients with non-valvular atrial fibrillation. This study

📍 Duke University Medical Center — Durham, North Carolina

Ultrasound Imaging of the Head, Neck, and Airway

Purpose and Objectives: The main purpose is to test an ultrasound device that can assess the upper airway to create dynamic 4D imaging, which current technology cannot do. Ultrasou

📍 Duke Hospital — Durham, North Carolina

Rehabilitation and Sex Therapy to Optimize Recovery After Prostate Cancer Treatment

This study is being done at Duke Health and includes adult men who have been treated for localized prostate cancer. The goal is to see if it is feasible and acceptable to offer sex

📍 Duke University Medical Center — Durham, North Carolina

💵 All enrolled participants will receive penile rehabilitation education and a vacuum erection device (VED) as part of sta

BMX-001 + Paclitaxel in Adult Patients With Advanced, Recurrent, Metastatic Ovarian or Endometrial Cancer

This research project addresses the urgent need for novel therapeutic strategies to overcome chemotherapy resistance and mitigate chemotherapy-induced peripheral neuropathy (CIPN)

📍 Duke Cancer Institute — Durham, North Carolina

💵 All participants will receive PTX at a dose of 80 mg/m² on the first day of each weekly cycle.

Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer

The purpose of this study is to develop a brief assessment and need-based behavioral intervention for addressing aging-specific concerns in older adults with lung cancer. The long-

📍 Duke University Health System — Durham, North Carolina

NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings

The investigators plan to conduct an R61/33 hybrid type 2 implementation-effectiveness trial that includes 1) a one-year exploratory R61 phase that will enable the development of t

📍 Duke University Medical System — Durham, North Carolina

Studies of Insulin and Glucagon Action in the Liver

This study examines how glucagon works to regulate glucose metabolism, based on new findings that suggest glucagon signaling in the liver has more than one role, and that these mul

📍 Duke Center for Living — Durham, North Carolina

Compact Auto-Aligning Multi-Modal Eye Imaging to Diagnose Traumatic Eye Injury

The purpose of this study is to test an investigational eye imaging device by taking pictures of participants eyes with a single image capture that takes only seconds.

📍 Duke Eye Center — Durham, North Carolina

ESP Blocks for Posterior Spinal Fusion

This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior

📍 Duke University — Durham, North Carolina

💵 Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine.

Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans

The investigators aim to support care partner's well-being and satisfaction with VA care and decrease their work burden by offering extra support from a trained Community Health Wo

📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina