33 Paid Clinical Research Studies in Oklahoma City, Oklahoma

Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)

This single arm phase II study proposes to evaluate the efficacy and safety of nab-sirolimus + endocrine therapy (Fulvestrant) in patients with recurrent low grade serous ovarian c

📍 OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma

💵 Patients will receive proposed treatment regimen of nab-sirolimus on days 1 and 8 and fulvestrant on days 1 and 15 of cy

"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer

The purpose of this study is to test the safety of palliative "QUAD SHOT" radiotherapy combined with pembrolizumab and evaluate the effects of the combination treatment patients wi

📍 Stephenson Cancer Center — Oklahoma City, Oklahoma

💵 During this study, patients will receive infusions of pembrolizumab with radiotherapy (palliative QUADSHOT regimen).

Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma

The purpose of this research study is to test the safety of avelumab and AVB-S6-500 and see what effects (good and bad) this combination treatment has on patients with advanced uro

📍 Stephenson Cancer Center — Oklahoma City, Oklahoma

💵 If found eligible, the patient will receive treatment with avelumab and AVB-S6-500 by vein once every two weeks.

Prostate Cancer Genius App Education and Home-based PSA Screening for African American Men

Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early dete

📍 TSET Health Promotion Research Center — Oklahoma City, Oklahoma

Tribally Engaged Approaches to Lung Screening (TEALS)

Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and AI/AN have worse lung cancer incidence rates, survival, and death compar

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

Implant Stability in Autogenous Mineralized and Demineralized Dentin Grafts

The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autogra

📍 University of Oklahoma College of Dentistry Graduate Periodontics — Oklahoma City, Oklahoma

AI_Colonoscopy_for_Fellows

The goal of this study is to look at how good artificial intelligence (AI) assisted colonoscopy is compared to conventional colonoscopy in detecting polyps when used by gastroenter

📍 Oklahoma City VA Health Care System — Oklahoma City, Oklahoma

Mobile App for Smoking Cessation and Mental Health

Adults with serious mental illness (SMI) represent 5% of the United States population, yet account for 30% of all cigarettes smoked and are 2 to 3 times more likely to be dependent

📍 Oklahoma Department of Mental Health and Substance Abuse Services — Oklahoma City, Oklahoma

Improving Sleep, Fatigue, Activity & Quality of Life in Cancer Survivors Via a Transdiagnostic Intervention

Poor sleep affects over half of U.S. cancer survivors, contributing to daytime fatigue, reduced physical activity, and diminished quality of life. Traditional sleep treatments ofte

📍 University of Oklahoma College of Allied Health — Oklahoma City, Oklahoma

Nebulized AER101 in Pre-op NSCLC

The primary objective of this pilot study is to determine if AER101 can decrease glycolysis in non-small cell lung cancer (NSCLC). Glycolysis is the process cells use to break down

📍 OU Medical Center Hospital — Oklahoma City, Oklahoma

💵 Each patient will receive a nebulizer and will self-administer the study drug 3 times a day for 14 days.

Evaluating the Addition of OK-1 Weekly Paclitaxel in Patients With Endometrial Cancer

The purpose of this study is to evaluate whether treatment with the investigational drug OK-1 in combination with paclitaxel can reduce tumor burden in patients with advanced or re

📍 OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma

💵 Participants will receive OK-1 capsules by mouth twice daily in continuous 21-day treatment cycles.

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screeni

📍 OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma

Performance of the Acoustic Based CADScor System in Coronary Artery Disease

The purpose of this study is to determine if the CAD Score, collected from the CADscore system, performs as well as the Coronary CTA in determining Coronary Artery Disease, in low

📍 INTEGRIS Baptist Medical Center — Oklahoma City, Oklahoma

Efficacy and Safety Assessment of Experimental Bleaching Agents

Tooth bleaching is widely used to treat the colors of teeth. This study compares the efficiency of two experimental bleaching gels, with and without nanoparticles, and with and wit

📍 The University of Oklahoma Health Sciences Center College of Dentistry — Oklahoma City, Oklahoma

Comparison Between Spectacles and Contact Lenses

Many people suffer from migraine headaches, some more so than others and a common trigger/complaint is light sensitivity, or photophobia1. Some will go to great lengths to avoid li

📍 Dean McGee Eye Institute — Oklahoma City, Oklahoma

Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)

This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/ad

📍 University of Oklahoma Health Campus — Oklahoma City, Oklahoma

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can al

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

Connect2Care: Prostate Cancer Education and Screenings for African American Men

Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early dete

📍 TSET Health Promotion Research Center — Oklahoma City, Oklahoma

💵 In both arms, participants will receive information about prostate cancer and screening, have access to a free at-home P

Cemiplimab or Cemiplimab and Fianlimab After Stereotactic Body Radiotherapy in Clear Cell Renal Cell Carcinoma

The purpose of this research is to test the safety of PD-1 inhibitor cemiplimab with or without LAG-3 inhibitor fianlimab, and see what effects (good and bad) of cemiplimab either

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

💵 During radiotherapy, patients will receive 1 to 5 fractions delivered over 1-2 weeks.

Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation

This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emerg

📍 Oklahoma Children's Hospital — Oklahoma City, Oklahoma

💵 The study will not be blinded once a patient is randomized to a group, the provider will know whether the patient will r

The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults

The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve b

📍 University of Oklahoma Health Campus — Oklahoma City, Oklahoma

Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

No published studies to date have evaluated the combined impact of varenicline and oral nicotine replacement therapy (NRT) on smoking cessation in a randomized trial. Oral NRT, suc

📍 TSET Health Promotion Research Center — Oklahoma City, Oklahoma

💵 All participants will receive 13 weeks of varenicline including the standard 1-week pre-quit titration period, with half

Binaural Cue Sensitivity in Children and Adults With Combined Electric and Acoustic Stimulation

There is a rapidly growing population of adult and pediatric cochlear implant (CI) recipients with acoustic hearing preservation in the implanted ear(s) allowing for combined Elect

📍 Hearts for Hearing — Oklahoma City, Oklahoma

Postural Control in Adults

The investigators propose a 2-week intervention involving adults over 65 years old. Participants will undergo dynamic balance training on an movable platform (stabilometer) with ei

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

A Culturally Tailored Smartphone Application for African American Smokers

The overall objectives of this research proposal, are to (a) create a smartphone application for smoking cessation (i.e., HealthyCells), which will be achieved by integrating two p

📍 TSET Health Promotion Research Center — Oklahoma City, Oklahoma

IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED

Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to opt

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II

This multi-method project will recruit young adults who currently use cigarillos and examine the effects of different flavored cigarillo types (concept, characterizing, tobacco) on

📍 TSET Health Promotion Research Center — Oklahoma City, Oklahoma

Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers

The goal of this observational study is to develop and evaluate a blood test for asymptomatic heavy smokers to screen for those at highest risk of developing lung cancer. The aim o

📍 Site 101 — Oklahoma City, Oklahoma

Outcomes in Simulated Endoscopy Training

Eligible participants are those who are members of the general surgery residency pediatric gastroenterology fellowship, and adult gastroenterology fellowship. Through a randomized-

📍 University of Oklahoma — Oklahoma City, Oklahoma

Efficacy of a Smartphone-Based JITAI to Reduce Drinking Among Adults Experiencing Homelessness

Approximately 1 out of every 3 adults experiencing homelessness has a current alcohol use disorder (AUD). Alcohol use plays a central role in increased morbidity and mortality in t

📍 University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma

💵 Eligible participants will receive training in our smartphone-based assessment platform and may be provided with a compa

Empowering Cessation ACS South Region

Sexual and/or gender minority (SGM) people face a disproportionate burden of cancer risk, and tobacco use is a key modifiable risk factor. SGM tobacco-related disparities are espec

📍 University of Oklahoma Health Campus — Oklahoma City, Oklahoma

Efficacy of the Buzzy System on Pain and Fear Reduction in Elbow Fracture Pin Removal

The goal of this study is to determine if the Buzzy System, a vibrating ice pack shaped like a bee reduces pain in removal of elbow fracture pin.

📍 OU Health Children's — Oklahoma City, Oklahoma

Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke

The goal of this study is to determine the efficacy of electromechanical exoskeleton-assisted gait training on rehabilitation functional outcomes in patients with stroke undergoing

📍 Oklahoma City VA Health Care System — Oklahoma City, Oklahoma

💵 All patients will receive their daily 3-hours conventional therapy, plus an hour of either exoskeleton or over-ground ga