33 Paid Clinical Research Studies in Philadelphia, Pennsylvania

Piloting a Patient Navigator Program for Weight Loss

Evidence-based interventions for overweight and obesity are underutilized. The utilization and efficacy of these interventions may improve with the implementation of a patient navi

📍 Drexel university — Philadelphia, Pennsylvania

Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers

This is a single blinded, randomized trial to evaluate the immediate subjective and objective effects of alcohol after a dose ketone supplement compared to a placebo in 10 health v

📍 University of Pennsylvania Center for Studies of Addiction — Philadelphia, Pennsylvania

Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study

We will conduct a Tau PET scan in cognitively normal older adults, enrolled in the Aging Brain Cohort Dedicated to Diversity Study (ABCD2-Tau) study at the University of Pennsylvan

📍 Hospital of the University of Pennsylvania - Penn Memory Center — Philadelphia, Pennsylvania

Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program

Men in the United States have an exceptionally high prevalence of overweight and obesity, i.e., 71.3%, and 42% of men are currently attempting weight loss. However, men are dramati

📍 Drexel University — Philadelphia, Pennsylvania

Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism

Autism Spectrum Disorder (ASD) represents one of the most perplexing neurobiological disorders with a prevalence of 1 in 54 children. The lifelong challenging and disruptive behavi

📍 University of Pennsylvania — Philadelphia, Pennsylvania

A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans

Despite the many associated health benefits, more than half of Veterans do not achieve enough regular physical activity. The investigators' prior work has demonstrated that gamific

📍 Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania

Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)

This phase II MATCH treatment trial tests how well BVD-523FB (ulixertinib) works in treating patients with cancer that has certain genetic changes. BVD-523FB (ulixertinib) is used

📍 ECOG-ACRIN Cancer Research Group — Philadelphia, Pennsylvania

The Effectiveness of an Autistic-delivered Peer-support Intervention for Autistic Adults: Community Autism Peer Specialist (CAPS) Program

The number of autistic adults reached 5.4 million in the United States in 2017 and is projected to continue to rise, but evidence-based practices to optimize their health and well-

📍 Drexel University — Philadelphia, Pennsylvania

CARTIMMUNE: Study of Patients With Autoimmune Diseases Receiving KYV-101

The purpose of this study is to assess the safety, tolerability, and clinical activity of KYV 101 (a fully-human anti-CD19 CAR T-cell therapy) in adult subjects with B cell-driven

📍 Hospital of the Universithy of Pennsylvania — Philadelphia, Pennsylvania

💵 Six participants in each autoimmune disease group for a total of 24 participants will receive a single dose of 1.0×10\[8

Implementing PrEP for Women Who Inject Drugs

Women who inject drugs are among the most vulnerable to acquiring HIV, but very few women who inject drugs are prescribed pre-exposure prophylaxis (PrEP) for HIV prevention largely

📍 University of Pennsylvania School of Nursing — Philadelphia, Pennsylvania

Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts

500 patients will be prospectively recruited to undergo a fast breast MRI examination. The women will be recruited for the study will meet the following criteria: 1. African Americ

📍 UPENN — Philadelphia, Pennsylvania

Effectiveness of Contrast-Enhanced Ultrasound

The purpose of the study is to generate pilot data describing test characteristics of contrast enhanced ultrasound in young children with concern for abdominal trauma. The primary

📍 Children's Hospital of Philadelphia — Philadelphia, Pennsylvania

Multi-System Analysis of Opioid Receptor Binding

This study will enroll up to 60 adults (including 30 females and 30 males) in three cohorts of up to 20 subjects each. In all three groups, \[11C\]carfentanil whole-body PET imagin

📍 University of Pennsylvania, Perelman School of Medicine — Philadelphia, Pennsylvania

Strengthening Intentions

participants are randomized to a study arm that measures intention to perform a health related behavior and follows up to measure behavior

📍 Penn Medicine — Philadelphia, Pennsylvania

Reducing Fatigue With CoQ10 Supplementation in Patients With Crohn's Disease Study

This study includes an open label clinical trial comparing two doses of CoQ10 for 8 weeks to improve fatigue among patients with Crohn's disease and a prospective cohort study of h

📍 University of Pennsylvania — Philadelphia, Pennsylvania

Effect of Nutritional Ketosis on Alcohol Metabolism

The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interv

📍 University of Pennsylvania Center for Studies of Addiction — Philadelphia, Pennsylvania

Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers

The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulat

📍 Thomas Jefferson University, Marcus Institute of Integrative Health Centers — Philadelphia, Pennsylvania

💵 All subjects will receive an initial evaluation using symptom questionnaires (these will include the Global Severity Ind

Wells and Enteric Disease Transmission

Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per

📍 Temple University — Philadelphia, Pennsylvania

Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma

Asthma-related deaths are more numerous among low-income minority patients and older adults with chronic diseases. Guidelines for asthma management have not addressed the needs of

📍 University of Pennsylvania Health Center — Philadelphia, Pennsylvania

Anti-GITR/Anti-PD1/Stereotactic Radiosurgery, in Recurrent Glioblastoma

This is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and stereotactic radiosurgery (SRS) f

📍 Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania

💵 These subjects will receive neoadjuvant INCMGA00012 + INCAGN01876 + SRS.

Nicotinic Hepatic Metabolism on Neuroreceptor Substrates of Nicotine Addiction

Physically healthy adult smokers may be eligible for this study. Volunteers may participate in this study if they are 18 - 65 years old. Subjects will participate in two separate

📍 University of Pennsylvania — Philadelphia, Pennsylvania

Fludarabine Based RIC for Bone Marrow Failure Syndromes

This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplasti

📍 Children's Hospital of Philadelphia — Philadelphia, Pennsylvania

💵 Acquired AA patients will receive the experimental regimen of fludarabine with dose-reduced cyclophosphamide, with resul

Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls

The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioact

📍 University of Pennsylvania — Philadelphia, Pennsylvania

Doula Model of Care

The goal of this randomized controlled intervention trial is to determine if an integrated partnership between a birth worker/community support organization and the Hospital of the

📍 Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania

FDG PET/CT in Breast Cancer Bone Mets

This study will evaluate baseline uptake on a FDG PET/CT scan in patients with breast cancer that has spread to the bones. A repeat FDG PET/CT scan will be done 4 weeks after the s

📍 University of Pennsylvania Hospital — Philadelphia, Pennsylvania

💵 This is an observational study as all patients will receive the same research diagnostic test, an FDG PET/CT study perfo

Tau PET Imaging in the NACC Study Cohort

The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). 18F-AV-1451 is a

📍 UPenn — Philadelphia, Pennsylvania

💵 Study Drug Administration: Subjects will receive a single IV bolus injection target dose of approximately 370 MBq (10 mC

Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in

📍 University of Pennsylvania — Philadelphia, Pennsylvania

💵 Subjects will receive each intervention for seven days, with a study day on day 7.

Air Pollution, Asthma and Circadian Clocks

Societies become increasingly urban - more than half the world's population now lives in cities. Urbanization elevates anthropogenic (man-made) exposure to air pollutants. A clear

📍 University of Pennsylvania School of Medicine — Philadelphia, Pennsylvania

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

There is growing recognition of the need for approaches to initiate treatment wherever patients touch the health care system, including the Emergency Department (ED). Most research

📍 University of Pennsylvania — Philadelphia, Pennsylvania

💵 Augmented usual care + text-message check-ins (standard Way to Health CareConnect Text line) Patients can call or text t

Analgesic Techniques for Rib Fractures

This study will be a 3-arm, parallel-group, randomized controlled trial comparing three analgesic techniques for rib fractures with a sample size of 24 patients (8 per group). Pati

📍 Thomas Jefferson University Hospital — Philadelphia, Pennsylvania

Investigation Into Detection of Prostate Cancer Using Voided Urine (Prostate VPAC)

The goal of this project is to detect prostate cancer cells, shed in voided urine, using the optical imaging method developed in our laboratory, which targets VPAC1 and STEAP1 rece

📍 Thomas Jefferson University Hospital — Philadelphia, Pennsylvania

TmPSMA-02 in mCRPC

This is a Phase I, open-label dose finding study to assess the safety, tolerability, manufacturing feasibility, and preliminary efficacy of TmPSMA-02 CAR T cells in patients with m

📍 Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania

💵 Dose escalation will begin with Dose Level 1 as follows: * Dose Level 1 (N = 3 to 6): Subjects will receive a single do

Edema and Fibrosis CMR Imaging in Cardiomyopathy

7 Tesla MRI is a new magnetic field strength that has become available at Penn for cardiovascular MRI. This new scanner has potential to improve assessment of cardiovascular diseas

📍 University of Pennsylvania — Philadelphia, Pennsylvania