26 Paid Clinical Research Studies in Charleston, South Carolina

CRP and S&A for Inpatient Veterans

The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems. Veterans admitted to the Charleston

📍 Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina

💵 All participant will receive TAU.

Spectral Characteristics of Memory Transformation

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning

📍 Medical University of South Carolina — Charleston, South Carolina

Brief, High-dose rTMS for Depression

High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational

📍 Medical University of South Carolina — Charleston, South Carolina

Peer Approaches to Lupus Self-management

The Peer Approaches to Lupus Self-Management (PALS) study is a randomized, controlled in which 360 African American women with lupus will be recruited from the MUSC SLE database (6

📍 Medical University of South Carolina — Charleston, South Carolina

Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection

The purpose of this study is to evaluate how useful vitamin D supplementation is in reducing the severity of COVID-19 symptoms and the body's inflammatory and infection-fighting re

📍 Medical University of South Carolina — Charleston, South Carolina

💵 All participants will receive a multivitamin containing vitamin D.

Citicoline in Youth Alcohol Use Disorder

The goal of this study is to evaluate how citicoline, an over-the-counter supplement, versus a placebo pill (i.e., an inactive pill) affects the immune system, brain, and cognition

📍 Medical University of South Carolina — Charleston, South Carolina

Dry Needling for Spasticity in Stroke

The study team is recruiting 20 adults with spasticity due to chronic stroke and 20 adults with no neurological injuries for a 2 day study. In people with chronic stroke, one of th

📍 Medical University of South Carolina — Charleston, South Carolina

Improving Maternal Mental Health & SUD Screening and Treatment

The purpose of the study is to compare a text message-based mental health and substance use screening and referral to a treatment program, called Listening to Women and Pregnant an

📍 Medical University of South Carolina — Charleston, South Carolina

Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy

This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulati

📍 Medical University of South Carolina — Charleston, South Carolina

Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.

📍 Medical University of South Carolina — Charleston, South Carolina

Simeox 200 US Study

The purpose of this single arm post-market observational study is to evaluate the short-term effectiveness of the Simeox 200 airway clearance device in improving airway clearance i

📍 Medical University of South Carolina — Charleston, South Carolina

💵 Follow-up Phone Call (14 days after V2): Participants will receive a follow-up phone call to assess ongoing symptoms and

Olfactory Dysfunction in Aging Adults

This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfact

📍 MUSC — Charleston, South Carolina

Thermodynamic Exposure and Sleep in Military Cadets

This pilot study investigates the effects of cold-water immersion, traditional sauna use, and their combination on sleep architecture and psychological health in military cadets. T

📍 The Citadel Military College — Charleston, South Carolina

taVNS or TMS or Both for Depression

The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with

📍 Medical University of South Carolina Institute of Psychiatry — Charleston, South Carolina

💵 First, participants will have a screening session and then will have 6 treatment days total where participants will rece

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role funct

📍 Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina

💵 Eligible participants will receive either (1) twelve sessions of BA-HT or (2) standard best practices post CVD hospitali

ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain

This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenor

📍 Medical University of South Carolina — Charleston, South Carolina

Systemic Lupus Erythematosus in Gullah Health

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunol

📍 Medical University of South Carolina — Charleston, South Carolina

Digitally Enhanced Stepped-Care for Depression in Primary Care

This pilot, three-arm randomized clinical trial (N=40; 2:1:1) will evaluate the feasibility and preliminary efficacy of a digitally enhanced stepped-care approach for depression tr

📍 Medical University of South Carolina — Charleston, South Carolina

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not

📍 Medical University of South Carolina — Charleston, South Carolina

RM1 Project 1 - tAN Naloxone

This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute t

📍 Medical University of South Carolina — Charleston, South Carolina

Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medicatio

📍 Medical University of South Carolina — Charleston, South Carolina

💵 As part of the therapy program, participants will receive access to a mobile application, which will be accessible for t

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

The purpose of this study is to develop and test if upper limb task practice and muscle activity training improve upper limb function in stroke survivors. Participants will be aske

📍 Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications. Everyone who participates in this stud

📍 Medical University of South Carolina — Charleston, South Carolina

💵 Most participants will receive some combination of these treatments, depending on individual response to each.

Autophagy Maintenance (AUTOMAIN)

This is a single-institution, single-arm study with a safety lead-in to determine if previously established safe doses of autophagy drugs, hydroxychloroquine (HCQ) and nelfinavir m

📍 Medical University of South Carolina — Charleston, South Carolina

💵 Patients will receive the two study drugs HCQ and NFV in combination with maintenance bevacizumab.

Accelerated TMS for Seizure-Type Functional Neurologic Disorders

The purpose of this project is to assess the feasibility, tolerability, and preliminary efficacy of using an accelerated, intermittent theta burst stimulation (a-iTBS-rTMS) protoco

📍 Institute of Psychiatry, Brain Stimulation Department — Charleston, South Carolina

💵 Following screening, consent, and enrollment, participants will receive 6-to-10 iTBS-rTMS sessions per day (i.e., theta

tFUS Induced Transient Scotoma for Individual Dosing

The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measure

📍 Medical University of South Carolina Brain Stimulation Division — Charleston, South Carolina