29 Paid Clinical Research Studies in Nashville, Tennessee

COVID-19 and Cancer Consortium Registry

In this study we will collect granular information on cancer patients infected with COVID-19, as rapidly as possible. The mechanism for collection of this information is a de-ident

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Treatment of Orthostatic Intolerance

This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the sympto

📍 Vanderbilt University Autonomic Dysfunction Center — Nashville, Tennessee

Acute Salt Handling in Orthostatic Intolerance

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve u

📍 Vanderbilt University — Nashville, Tennessee

Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Competency Based Approaches for Community Health 2

One-size-fits-all approaches have failed to demonstrate sustained effects on childhood obesity, especially among low-income minority families, who experience constantly changing ba

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects

📍 Vanderbilt University — Nashville, Tennessee

Combined Treatment Sofwave and Pure Impact to Strength and Tone Muscles and Improve Lax Skin Appearance

Open-label, non-randomized, prospective, multi-center, self-controlled clinical study.

📍 Tennessee Clinical Research Center — Nashville, Tennessee

💵 Eligible patients will receive combined treatment on both upper arms, included 1 or 2 SofWave treatments and 4 Pure Impa

Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome

In this pilot study, the investigators will test the hypothesis that patients with postural tachycardia syndrome will have an elevated percentage of functional antibodies to adrene

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Combinatorial Single Cell Strategies for a Crohn's Disease Gut Cell Atlas

Inflammatory bowel disease (IBD), consisting of two major forms, Crohn's disease (CD) and ulcerative colitis, affects more than 1.6 million people in the United States alone. Despi

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Improving Care After Inherited Cancer Testing

The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genet

📍 Vanderbilt-Ingram Cancer Center — Nashville, Tennessee

Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening

The purpose of the study is to determine whether patients meet criteria for Postural Tachycardia Syndrome (or not) and have reduced blood volume (or not). Both of these are importa

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension. The investigato

📍 Autonomic Dysfunction Center — Nashville, Tennessee

Long COVID Immune Profiling

Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is assoc

📍 Cyndya Shibao — Nashville, Tennessee

Surgery for Cancer With Option of Palliative Care Expert

Frequently people diagnosed with cancer experience physical and emotional symptoms during the course of their disease. These symptoms can be very distressing to both the patient an

📍 Vanderbilt University Medical Center — Nashville, Tennessee

💵 Intervention arm patients will receive a preoperative outpatient specialty palliative care consultation from a palliativ

DOMPE -MT Neurotrophic Keratitis

TITLE: Toyos Clinic / A Phase 4 Study to Assess Longer Duration of Treatment with Cenegermin in Moderate to Severe Dry Eye-Associated Neurotrophic Keratitis

📍 Toyos Clinic — Nashville, Tennessee

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated gluco

📍 Autonomic Dysfunction Center — Nashville, Tennessee

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in

📍 Vanderbilt University Medical Center — Nashville, Tennessee

3D Specimen Maps for RT Planning

The primary objective of this study is to measure the impact of patient-specific 3D specimen maps on adjuvant radiation treatment volumes and doses to critical organs. All patients

📍 Vanderbilt Medical Center — Nashville, Tennessee

💵 All patients will receive standard-of-care post-operative radiotherapy not impacted by the experimental 3D specimen maps

Quantitative Imaging of Brain Glymphatic Function in Humans

Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary

📍 Vanderbilt University Medical Center — Nashville, Tennessee

💵 As such, while this study qualifies as a clinical trial by NIH criteria, it is expected to pose no more risk than what t

POTS NET mRNA Functional Correlation With NET Activity

DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Pathophysiology of Orthostatic Intolerance

The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. The syndrome is of undetermined etiology, but th

📍 Vanderbilt University — Nashville, Tennessee

Autonomic Determinants of POTS - Pilot1

Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. It is the cause of significant disability and an impairment in

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Health Coaching for Back Pain After Emergency Department Discharge

The goal of this two-group randomized trial is to determine the feasibility and acceptability of a remotely-delivered health coaching intervention offered in conjunction with usual

📍 Tennessee Valley Healthcare System - Nashville VA Medical Center — Nashville, Tennessee

💵 Randomized participants will receive 8 calls from either a health coach or education provider, and be asked to complete

Study of Changes in Skeletal Muscle After Caloric Restriction

Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose. The purpose of this study is to examine the effec

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Tennessee Youth Prepared for Success

The principal objective of Tennessee Youth Prepared for Success is to pilot, implement, and test innovative adolescent pregnancy prevention strategies using a randomized controlled

📍 Centerstone Research Institute — Nashville, Tennessee

Interventions for Reading Disabilities in NF1

Neurofibromatosis Type 1 (NF1) is a common genetic disorder that is associated with a four times greater risk of learning disabilities, including reading disabilities, and a defici

📍 Vanderbilt University — Nashville, Tennessee

This Study Will Look at How Elevated Na+ Alters the Gut Microbiota, Particularly in Salt-sensitive Individuals, and is Associated With Inflammation, Metabolic Changes, and SSBP. The Study Will Examine 50 Individuals Using Randomized Crossover Trial Design.

The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pr

📍 Vanderbilt University Medical Center — Nashville, Tennessee

Lazarus: IT Therapy for ICANS

The goal of this clinical trial is to reduce the duration of ICANS and incidence of G3 or great ICANS in participants who receive axi-cel. The main questions the study aims to answ

📍 Vanderbilt University/Ingram Cancer Center — Nashville, Tennessee

💵 Lymphodepleting Chemotherapy and CAR T Cell Administration Period- Participants will receive standard fludarabine and cy

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, ph

📍 Vanderbilt University Medical Center — Nashville, Tennessee

💵 Participants will receive calcium-HMB plus vitamin D3 or matching placebo for approximately 6 months.