30 Paid Clinical Research Studies in Milwaukee, Wisconsin

Heat, Microvascular Function and Aging

Vascular dysfunction is a common factor in many chronic debilitating diseases, contributing to morbidity and mortality. With the onset of chronic disease or exposure to stress, the

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Intensive Postpartum Antihypertensive Treatment

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversa

📍 Froedtert Hospital — Milwaukee, Wisconsin

Preventing Obstetric Complications With Dietary Intervention

The goal of this study is to learn whether access to healthy and fresh food, health coaching, and nutrition support intervention can reduce adverse birth outcomes in pregnant women

📍 Froedert & The Medical College of Wiscosin — Milwaukee, Wisconsin

Elimination of Minimal Residual Disease After Transplant

This is a single-center, single-arm, phase II study that will enroll multiple myeloma (MM) patients with persistent bone marrow minimal residual disease (MRD) post autologous stem

📍 Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Enrolled subjects will receive a combination of isatuximab, lenalidomide, and dexamethasone (IsaRD) for 12 28-day cycles

De-escalated Cyclophosphamide (PTCy) and Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis

This is an open-label phase 2 study designed to explore the efficacy and safety of low-dose PTCy-ruxolitinib GVHD prophylaxis in older adults undergoing allogeneic HCT with a match

📍 Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Following reduced intensity conditioning and 8/8-matched peripheral blood transplant on Day 0, all patients will receive

Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma

Patients are randomized into two arms. Arm A patients will receive Stereotactic Body Radiation Therapy (SBRT) and Arm B patients with receive conventional concurrent chemotherapy a

📍 Froedtert Hospital & Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Arm A patients will receive Stereotactic Body Radiation Therapy (SBRT) and Arm B patients with receive conventional conc

Cardiometabolic Health in Transgender Males

Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to \~60,000 trans

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

HD-tDCS for Phonological Impairment in Aphasia

This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Patients will receive one of two different speech therapy treatment interventions to focus on specific processing defici

Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)

This is a phase 1 study to determine the safety of a condensed preoperative radiation regimen (10, 7, or 5 fractions) for the management of head and neck squamous cell carcinoma.

📍 Froedtert Hospital and the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 The subjects will receive smaller number of fractions (total visits) but with a higher dose of radiation with each Dose

Vascular Aging and Lp299v Study in Healthy Adults

Emerging data suggest the gut microbiota regulates multiple mechanisms related to vascular aging, but no intervention targeting the gut microbiota has been tested in older adults w

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain

Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculosk

📍 Zablocki Veterans Affairs Medical Center — Milwaukee, Wisconsin

Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation t

📍 Marquette University School of Dentistry Graduate Periodontics Clinic — Milwaukee, Wisconsin

Puerto Rican Obesity Intervention for Men

The goal of this clinical trial is to address the high rates of overweight/obesity in Puerto Rican (PR) men. The main question it aims to answer is whether virtual culturally relev

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Pacritinib in Participants With Metastatic Castrate-Resistant Prostate Cancer That Progressed on or After Prior Treatment With Androgen Receptor Signaling Inhibitors

This is a single-arm, open-label phase 2 study to evaluate the role of pacritinib for patients with metastatic castrate-resistant prostate cancer that have progressed on ARSI. Pati

📍 Froedtert & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Patients will receive pacritinib 200 mg twice daily.

Stimulation-based Therapy to Improve Balance in DCM

The goal of this clinical trial is to determine if a treatment called transcutaneous spinal cord stimulation (tSCS), when combined with balance training, can help improve balance i

📍 Marquette University — Milwaukee, Wisconsin

💵 * Participants will receive stimulation or sham treatment during these sessions.

Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes

Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also l

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Prevention of Recurrence of Clostridioides Difficile Colitis With Ursodeoxycholic Acid (UCDA) as a Supplement to Standard Therapy

The goal of this clinical trial is to determine whether Ursodeoxycholic Acid (UDCA) can help prevent recurrence of Clostridioides difficile (C. diff) colitis when used along with s

📍 Daniel Stein — Milwaukee, Wisconsin

💵 Each participant will receive standard antibiotic treatment, which may include Vancomycin, Fidaxomicin, or Metronidazole

Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP

The goal of this open label, randomized, non-inferiority clinical trial is to compare the treatment success of a 5 day antibiotic course versus a standard antibiotic course (usuall

📍 Childrens Wisconsin — Milwaukee, Wisconsin

💵 In the experimental group, the participant will receive a total antibiotic course of 5 days.

Cilta-Talq Fusion Study: A Phase 1b Study of Talquetamab Bridging Therapy Followed by Ciltacabtagene Autoleucel in Patients With Relapsed/Refractory Multiple Myeloma

This is a single-arm, open-label, phase 1b study evaluating the safety and feasibility of using talquetamab as bridging therapy prior to cilta-cel in patients with relapsed and ref

📍 Froedtert & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Following apheresis, patients will receive one cycle of talquetamab therapy.

Transcranial Alternating Current Stimulation (tACS) in Aphasia

This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Language Processing and TMS

This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

This prospective, two-part, single-arm, phase II trial is designed to evaluate whether the use of definitive radiation to the primary lung lesion prolongs progression-free survival

📍 Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Twenty-nine subjects will receive a standard-of-care targeted TKI therapy.

Peripheral Blood Flow Responses to Electromagnetic Energy

This study evaluates 670 nm energy in the form of red light to stimulate blood flow changes in healthy adults. All participants will receive red light to their leg. They will also

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

💵 All participants will receive red light to their leg.

Mechanisms Preventing Pharyngeal Reflux

The overall goal is to define and characterize the manometric characteristics of UES incompetence associated with objectively documented pharyngeal reflux. The investigators will u

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor h

📍 Marquette University — Milwaukee, Wisconsin

Exercise Training in Children With Communication Impairments

This clinical trial study has two goals. The first goal is to establish fitness levels, participation in physical activities, and fine/gross motor abilities for children with devel

📍 Marquette U — Milwaukee, Wisconsin

Older Age and Generalization

The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do olde

📍 University of Wisconsin-Milwaukee — Milwaukee, Wisconsin

Individuals on Hormone Therapy Breast Cancer Screening Pilot

This investigation is a prospective breast cancer screening study open to all individuals on hormone therapy. Using a mixed methods approach, the study will 1) gather prospective q

📍 Medical College of Wisconsin — Milwaukee, Wisconsin

Venetoclax to Augment Epigenetic Modification and Chemotherapy

The investigator is testing the addition of venetoclax to 5-azacitidine and vorinostat followed by standard chemotherapy to enhance treatment response in AML patients.

📍 Children's Wisconsin — Milwaukee, Wisconsin

💵 Subjects will receive two 35 day cycles of therapy.

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions

📍 Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin

💵 Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of reg