A Phase I/II Study of Hypofractionated Proton Therapy for Stage II-III Non-Small Cell Lung Cancer (NCT01770418)

🧪 Interventions in This Study

• Radiation with Concurrent Chemotherapy (RADIATION)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. Pathologically confirmed invasive non-small cell lung cancer within 12 weeks prior to study registration. OR Pathologically confirmed invasive non-small cell lung cancer within 6 months prior to study registration if the patient received induction chemotherapy.
2. AJCC (American Joint Committee on Cancer) 7th Ed. clinical stage II-III.
3. ECOG Performance status 0-1 within 8 weeks prior to study registration.
4. Patient must give study-specific informed consent on an IRB-approved consent prior to any research-related procedures or study treatment.
5. Patient must be at least 18 years old at the time of consent.
6. Patient must complete all required tests in section 4.
7. Lab results per the following within 4 weeks prior to study registration:
8. Absolute neutrophil count (ANC) \>1,800 cells/mm3.
9. Platelets \> = 100,000 cells/mm3.
10. Hemoglobin \> =10 g/dl. The use of transfusion or other intervention to achieve Hgb ≥10.0 g/dl is acceptable.
11. AST/SGOT and ALT/SGPT \< 2.5 x the institutional upper limit of normal (IULN).
12. Post exploratory thoracotomy must be done \> 3 weeks prior to study registration or patient did not have post exploratory thoracotomy.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (6 Sites)

• University of Florida Proton Therapy Institute — Jacksonville, Florida
• Northwestern Medicine Chicago Proton Center — Warrenville, Illinois
• Maryland Proton Treatment Center — Baltimore, Maryland
• Princeton ProCure Management LLC — Somerset, New Jersey
• Oklahoma Proton Center — Oklahoma City, Oklahoma
• Hampton University Proton Therapy Institute — Hampton, Virginia

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Review the official NIH record below to find the coordinating site.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.