Theophylline Treatment for Pseudohypoparathyroidism (NCT03029429)
Phase 2 Study of Theophylline Treatment for Pseudohypoparathyroidism
🩺 Plain-English Summary (8th-Grade Level)
Pseudohypoparathyroidism is a genetic disorder with limited treatment options. Patients have early-onset obesity, short stature and increased risk of type 2 diabetes. This phase 2 clinical trial will test the efficacy of theophylline, a phosphodiesterase inhibitor, in pseudohypoparathyroidism. The investigators hypothesize that theophylline will cause weight loss, improve glucose tolerance and slow growth plate closure in children and young adults.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (15 items).
Location: Jaclyn Tamaroff — Nashville, Tennessee
Age range: 13 Years to 99 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Use of a PDE inhibitor in the past 30 days
- History of a seizure disorder unrelated to hypocalcemia
- History of a cardiac arrhythmia (not including bradycardia)
- Hepatic insufficiency including cirrhosis and acute hepatitis (AST or ALT \>3x upper limit of normal)
- Congestive heart failure
- Current cigarette use or alcohol abuse
- Pregnancy or intention to become pregnant during the next year
- Untreated hypothyroidism (defined as free thyroxine below the lower limit of normal)
- Active peptic ulcer disease
- Current use of medications known to effect theophylline levels
- History of hypersensitivity to theophylline or other medication components
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Jaclyn Tamaroff — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Pseudohypoparathyroidism
- Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old — Nashville, Tennessee
Explore by condition: All Pseudohypoparathyroidism clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.