Reversal of Atrial Substrate to Prevent Atrial (NCT03682991)
Reversal of Atrial Substrate to Prevent Atrial Fibrillation
🩺 Plain-English Summary (8th-Grade Level)
A multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on recurrence of atrial fibrillation.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (10 items).
Location: Foothills Hospital — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
- Aggressive Risk Factor Control (OTHER)
- Standard of Care (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Permanent AF (AF lasting \> 3 years)
- Prior catheter ablation for AF
- New York Heart Association (NYHA) Class IV (Severe) heart failure,
- Participation in a cardiac rehabilitation program within the last year,
- Currently performing exercise training \>150 minutes/week of moderate to vigorous physical activity,
- Unable to exercise,
- Unable to give informed consent,
- Other noncardiovascular medical condition making 1 year survival unlikely,
- Less than 18 years of age.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (17 Sites)
- Foothills Hospital — Calgary, Alberta
- Mazankowski Alberta Heart Institute — Edmonton, Alberta
- Kelowna General Health — Kelowna, British Columbia
- St. Paul's Hospital — Vancouver, British Columbia
- Saint John Regional Hospital — Saint John, New Brunswick
- QE II Health Sciences Centre — Halifax, Nova Scotia
- Hamilton Health Sciences Center — Hamilton, Ontario
- St. Mary's General Hospital — Kitchener, Ontario
- London Health Sciences Center — London, Ontario
- Ottawa Heart Institute — Ottawa, Ontario
- St. Michael's Hospital — Toronto, Ontario
- Sunnybrook Health Sciences Centre — Toronto, Ontario
- Laval Hospital — Laval, Quebec
- McGill University Health Centre — Montreal, Quebec
- Montreal Heart Institute — Montreal, Quebec
- Sacre Coeur Hospital — Montreal, Quebec
- Regina General Hospital — Regina, Saskatchewan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Atrial Fibrillation
- HeartBeam ECG Registry — Pittsburgh, Pennsylvania
- Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer — Portland, Oregon
- CHAMPION-AF Clinical Trial — Birmingham, Alabama
- Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation — Chicago, Illinois
- Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients — Rochester, New York
Explore by condition: All Atrial Fibrillation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.