🏛️ Verified NIH Record • Updated 2026-05-28

Atrasentan in Patients With Proteinuric Glomerular Diseases (NCT04573920)

A Phase 2, Open-Label, Basket Study of Atrasentan in Patients With Proteinuric Glomerular Diseases

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals

🩺 Plain-English Summary (8th-Grade Level)

The AFFINITY Study is a phase 2, open-label, basket study to evaluate the efficacy and safety of atrasentan in patients with proteinuric glomerular disease who are at risk of progressive loss of renal function.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (23 items) and avoid the listed exclusions (14 items).

Location: Kidney Disease Medical Group — Glendale, California

Age range: 18 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Current diagnosis of another cause of chronic kidney disease or another primary glomerulopathy.
  • History of kidney transplantation or other organ transplantation.
  • Except for FSGS patients, use of systemic immunosuppressant medications, such as steroids, for more than 2 weeks in the past 3 months.
  • Blood pressure above 150 mmHg systolic or 95 mmHg diastolic as evaluated by the Investigator.
  • History of heart failure or a previous hospital admission for fluid overload.
  • Clinically significant history of liver disease as assessed by the Investigator.
  • Hemoglobin below 9 g/dL as measured by the Investigator or blood transfusion for anemia within the past 3 months.
  • Clinical diagnosis of nephrotic syndrome
  • Malignancy within the past 5 years. Exception to the criteria include nonmelanoma skin cancer and curatively treated cervical carcinoma in situ.
  • For women, pregnant, breastfeeding, or intent to become pregnant during the study.
  • For men, intent to father a child or donate sperm during the study.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (33 Sites)

Showing the first 25 of 33 sites.

  • Kidney Disease Medical Group — Glendale, California
  • Academic Medical Research Institute — Los Angeles, California
  • North America Research Institute — San Dimas, California
  • Stanford U School Of Medicine — Stanford, California
  • Colorado Kidney Care Nephrology — Denver, Colorado
  • Northwest Louisiana Nephrology Research — Shreveport, Louisiana
  • Tufts Medical Center — Boston, Massachusetts
  • Uni of Minnesota Hos and Clinics — Minneapolis, Minnesota
  • DaVita Clinical Research — Las Vegas, Nevada
  • Mountain Kidney And Hyper Associa — Asheville, North Carolina
  • Brookview Hills Research Assoc — Winston-Salem, North Carolina
  • Baylor Scott and White — Dallas, Texas
  • Prolato Clinical Research Center — Houston, Texas
  • Milwaukee Nephrologists SC — Wauwatosa, Wisconsin
  • Novartis Investigative Site — Gosford, New South Wales
  • Novartis Investigative Site — Herston, Queensland
  • Novartis Investigative Site — Clayton, Victoria
  • Novartis Investigative Site — Reservoir, Victoria
  • Novartis Investigative Site — St Albans, Victoria
  • Novartis Investigative Site — St Leonards,
  • Novartis Investigative Site — Roma, RM
  • Novartis Investigative Site — Cheonan, Chungcheongnam-do
  • Novartis Investigative Site — Anyang-si, Gyeonggi-do
  • Novartis Investigative Site — Seoul, Korea
  • Novartis Investigative Site — Seoul,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗