Dual Frequency Stimulation in Parkinson's Disease (NCT04650932)
Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
🩺 Plain-English Summary (8th-Grade Level)
Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (7 items).
Location: UC Davis Health — Sacramento, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Individuals unable to provide consent and/or lack capacity to consent
- Individuals diagnosed with any cognitive or physical impairments that would limit their ability to participate in the cognitive testing
- Individuals who score below 15 on the Montreal Cognitive Assessment Test-Blind
- Individuals who score above 20 on the Center for Epidemiologic Studies Depression Scale
- Pregnant women (note: pregnant women are not candidates for DBS surgery), and prisoners
- Non-English speaking individuals. Cognitive tasks will only be conducted in English.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- UC Davis Health — Sacramento, California
📞 Contact the Study Coordinator
Phone: (916) 703-5505
Email: krshahlaie@ucdavis.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Parkinson Disease
- Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation — Tucson, Arizona
- A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations — Little Rock, Arkansas
- Investigating Inhibitory Control Networks in Parkinson's Disease — Birmingham, Alabama
- Parkinson's Disease Progression Study — Aurora, Colorado
- The GBA Multimodal Study in Parkinson's Disease — Portland, Oregon
- Speech Amplification Devices for Parkinson Disease: Talker- and Technology-Driven Enhancements — East Lansing, Michigan
Explore by condition: All Parkinson Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.