Who is eligible for clinical trial NCT04663841?

Participants must meet the protocol's inclusion criteria for Depression. The stated age range is 18 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT04663841 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-12-30

Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study (NCT04663841)

Mechanistic Circuit Markers of Transcranial Magnetic Stimulation Outcomes in Pharmacoresistant Depression

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Stanford University

🩺 Plain-English Summary (8th-Grade Level)

This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of change with TMS. We address this objective through a pragmatic approach in which we recruit patients undergoing routine clinical care and program evaluation in a Veterans Administration multi-site clinical TMS program.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (15 items).

Location: Stanford University Department of Psychiatry — Stanford, California

Age range: 18 Years

🧪 Interventions in This Study

transcranial magnetic stimulation (OTHER)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Ages 18 years and older
Meets Diagnostic and Statistical Manual edition 5 (DSM-5) criteria for Major Depressive Disorder (MDD) (as documented by the treating physician)
Meet study criteria for pharmacoresistance in accordance with the Clinical transcranial magnetic stimulation (TMS) Program (i.e. failed at least one antidepressant in the current episode)
Ability to obtain a motor threshold (MT) prior to the start of treatment
Stable medical conditions and ability to maintain stability on current medication regimen for the duration of treatment
Ability to participate in a daily treatment regimen
Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
History of seizure disorder
Structural or neurologic abnormalities present or in close proximity to the treatment site
History of brain surgery
Pacemaker or medical infusion device (unless magnetic resonance imaging compatible)
History of traumatic brain injury within 60 days of the start of treatment
Severe or uncontrolled alcohol or substance use disorders
Active withdrawal from alcohol or substances
Implanted device in the head
Metal in the head
Severe impediment to vision, hearing and/or hand movement, likely to interfere with ability to complete the assessments, or unable and/or unlikely to follow the study protocols
Lifetime history of bipolar I disorder

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Stanford University Department of Psychiatry — Stanford, California

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Depression

To Improve Depressive Symptoms Using a Web-App — Austin, Texas
Pilot Randomized Trial of BA-GSH in VA PC-MHI — Houston, Texas
Neurocardiac Predictors of Treatment Response to RTMS in Depression — Vancouver, British Columbia
Cognition and Behavior With Sham Accelerated TMS — Sacramento, California
Meditation Accelerated Brain Stimulation for Depression — San Diego, California

Explore by condition: All Depression clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗