Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain (NCT04744883)
Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain
🩺 Plain-English Summary (8th-Grade Level)
Chronic Pain Management (CPM) has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (a greater exposure in vulnerable individuals), non-pain health consequences (hormone changes, falls), and a dramatic rise in opioid-related overdoses and deaths. Treatment strategies that minimize the need for chronic high-dose opioids are sorely needed. This project will aim to test what degree mindfulness therapy (MT) and spinal manipulation therapy (SMT) produce pre- to mid- to post-treatment changes in endogenous opioid (EO) function.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (17 items).
Location: Rush University Medical Center — Chicago, Illinois
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- meet criteria for alcohol or substance abuse problems
- meet criteria for past or present psychotic or bipolar disorders
- inability to understand English well enough to complete questionnaires or participate in therapy
- pain due to malignant conditions, rheumatoid arthritis, migraine or tension headache, complex regional pain syndrome, or fibromyalgia syndrome
- lumbar surgery within past 6 months
- pregnant
- signs of nerve root compression (ie, positive straight-leg raise \<45○).
- liver diseases (e.g hepatitis or cirrhosis)
- suicide ideation with intent
- osteoporosis or bone demineralization
- opioid-dependency
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (2 Sites)
- Rush University Medical Center — Chicago, Illinois
- Vanderbilt University Medical Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Chronic Low-back Pain
- Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain — Aventura, Florida
- Psilocybin Therapy for Chronic Low Back Pain — San Francisco, California
- Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain — San Francisco, California
- Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain — Kansas City, Kansas
- Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management. — Kansas City, Kansas
- Psilocybin in Chronic Low Back Pain and Depression — Baltimore, Maryland
Explore by condition: All Chronic Low-back Pain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.