Lorlatinib Continuation Study (NCT05144997)
LORLATINIB (PF-06463922) CONTINUATION PROTOCOL: AN OPEN-LABEL, SINGLE-ARM CONTINUATION STUDY FOR PARTICIPANTS WITH ALK-POSITIVE OR ROS1-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC) CONTINUING FROM PFIZER SPONSORED LORLATINIB CLINICAL STUDIES
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this protocol is to provide continued treatment access and safety follow-up for eligible participants who continue to derive a benefit from study intervention in the Pfizer sponsored lorlatinib parent studies that will be closed. Additional follow-up safety data collection will permit further characterization of the safety profile of lorlatinib in participants continuing to receive study intervention
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (1 items) and avoid the listed exclusions (1 items).
Location: Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria: 1 - Female participants who are pregnant or breastfeeding. 2- Any medical reason that, in the opinion of the Investigator or Sponsor, precludes the participant from inclusion in the study.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (27 Sites)
Showing the first 25 of 27 sites.
- Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California
- The First affiliated Hospital of Anhui Medical University — Hefei, Anhui
- Beijing Chest Hospital, Capital Medical University — Beijing, Beijing Municipality
- Beijing Cancer Hospital — Beijing, Beijing Municipality
- Fujian Cancer Hospital — Fuzhou, Fujian
- Guangdong Provincial People's Hospital — Guangzhou, Guangdong
- Hunan Provincial Tumor Hospital — Changsha, Hunan
- General Hospital of Eastern Theater Command — Nanjing, Jiangsu
- Jilin Cancer Hospital — Changchun, Jilin
- The first hospital of jilin university — Changchun, Jilin
- Sir Run Shaw Hospital — Hangzhou, Qiantang District
- The Second Affiliated Hospital of PLA Air Force Medical University — Xi'an, Shaanxi
- Shanghai Chest Hospital — Shanghai, Shanghai Municipality
- Sichuan Cancer hospital — Chengdu, Sichuan
- The First Affiliated Hospital Zhejiang University School of Medicine — Hangzhou, Zhejiang
- Zhejiang Cancer Hospital — Hangzhou, Zhejiang
- The Second Affiliated Hospital of Zhejiang University College of Medicine — Hangzhou, Zhejiang
- Fudan University Shanghai Cancer Center — Shanghai,
- CHU de Rennes - Hôpital Pontchaillou — Rennes,
- Institut Gustave Roussy — Villejuif,
- Healthcare Global Enterprises — Bengaluru, Karnataka
- Bhaktivedanta Hospital & Research Institute — Thane, Maharashtra
- Aichi Cancer Center Hospital — Nagoya, Aichi-ken
- National University Hospital — Singapore,
- National Cancer Centre Singapore — Singapore,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.