Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY) (NCT05148715)
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)-Pilot Trial
🩺 Plain-English Summary (8th-Grade Level)
The investigators hypothesize that preconditioning neurologically deceased organ donors with the calcineurin inhibitor tacrolimus will improve short and long-term transplant survival without causing harm. Organ donors will be randomized to receive either 0.02 mg/kg ideal body weight (IBW) of tacrolimus single infusion or placebo before organ recovery. All corresponding recipients are enrolled and data is collected up to 7 days post-transplant to determine graft function and at 1 year to collect outcomes of vital status, re-transplantation and dialysis. The CINERGY Pilot Trial assesses feasibility for the main trial.
Who can join: Review the eligibility criteria below.
Location: Vancouver General Hospital — Vancouver, British Columbia
Age range: 18 Years to 100 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (9 Sites)
- Vancouver General Hospital — Vancouver, British Columbia
- St. Paul's Hospital — Vancouver, British Columbia
- L'Institut de Cardiologie de Montréal — Montreal, Quebec
- Hôpital Maisonneuve-Rosemont — Montreal, Quebec
- Centre Hospitalier Universitaire de Montréal — Montreal, Quebec
- Centre universitaire de santé McGill (CUSM) — Montreal, Quebec
- Centre Hospitalier Universitaire de Québec- Université Laval — Québec, Quebec
- Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) — Québec, Quebec
- Centre de recherche CHUS — Sherbrooke, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Organ Transplant Failure or Rejection clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.