Who is eligible for clinical trial NCT05443906?

Participants must meet the protocol's inclusion criteria for Neurodegenerative Diseases. The stated age range is 5 Years to 75 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT05443906 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-03-06

Home Exercise for Individuals with Neurodegenerative Disease (NCT05443906)

Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals with Neurodegenerative Disease

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

🩺 Plain-English Summary (8th-Grade Level)

The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (2 items).

Location: Kennedy Krieger Institute — Baltimore, Maryland

Age range: 5 Years to 75 Years

🧪 Interventions in This Study

Home exercise (BEHAVIORAL)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.
The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.
The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.
For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.
We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam. Healthy Volunteers
Able to stand for 30 seconds without upper extremity support
Ambulatory (including use of a cane or a walker)
Able to walk for 2 minutes

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Other medical or psychological conditions which in the clinical judgement of the investigator would interfere with acquiring the study information or performing the exercises safely including but not limited to: Uncontrolled hypertension, orthopedic conditions, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Kennedy Krieger Institute — Baltimore, Maryland

📞 Contact the Study Coordinator

Phone: (443) 923-2716

Email: keller@kennedykrieger.org

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗