SV2A Density Cannabis Use Disorder (NCT05472818)
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal \[11C\]APP-311/\[11C\]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic vesicle density will be placed in functional context by measuring verbal memory, which is sensitive to hippocampal function, before and after at least 4 weeks of confirmed abstinence. Finally, the relationship between hippocampal \[11C\]UCB-J binding in CUDs with measures of cannabis exposure (e.g., age of initiation, cumulative lifetime dose) will be explored.
Who can join: Review the eligibility criteria below.
Location: Yale University School of Medicine — New Haven, Connecticut
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Yale University School of Medicine — New Haven, Connecticut
📞 Contact the Study Coordinator
Phone: (203) 974-7822
Email: shannon.zeilman@yale.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cannabis Use Disorder
- Cannabidiol and Cannabis Concentrate Users — Aurora, Colorado
- RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative — New York, New York
- A Brief Intervention for Cannabis Use — Charleston, South Carolina
- SCORE Emerging Adult Cannabis Use & Stress — Charleston, South Carolina
- Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder — Toronto, Ontario
Explore by condition: All Cannabis Use Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.