Who is eligible for clinical trial NCT05512754?

Participants must meet the protocol's inclusion criteria for Elevated Serum PSA. The stated age range is 18 Years to 80 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT05512754 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-12-02

Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen (NCT05512754)

Randomized Controlled Trial of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: University of Chicago

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the impact of ibuprofen in men with elevated serum PSA.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (13 items).

Location: University of Chicago — Chicago, Illinois

Age range: 18 Years to 80 Years

🧪 Interventions in This Study

Ibuprofen 400 mg (DRUG)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Male patients age between 18-80 years old with a screening PSA \> 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy)
Normal digital rectal examination.
No clinical symptoms concerning acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture)

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Active urinary tract infections or bacteriuria
Known prostate cancer
Urethral catheter within the last 6 weeks
History of hypersensitivity or allergy to ibuprofen or NSAIDs.
Known severe chronic kidney disease: eGFR \< 30 mL/min/1.73 m2
Known history of severe liver disease (elevated AST or ALT greater than 3 times upper limit of normal)
History of gastrointestinal bleeding or NSAIDs induced GI adverse events
Concomitant dual-antiplatelet use or anticoagulants
Concomitant anti-inflammatory or steroidal drugs
Known bleeding disorder(s)
Patients with a solitary kidney or history of a kidney transplant

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (3 Sites)

University of Chicago — Chicago, Illinois
Albany Medical College — Albany, New York
The Pennsylvania State University at The Milton S. Hershey Medical Center — Hershey, Pennsylvania

📞 Contact the Study Coordinator

Phone: (773) 834-5087

Email: seggener@bsd.uchicago.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Elevated Serum PSA clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗