The Neuroendocrine Effects of Pioglitazone in Patients With Cancer and Cachexia (NCT05919147)
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Neuroendocrine Effects of Pioglitazone in Patients With Cancer and Cachexia
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is evaluate the effect of pioglitazone compared with placebo on skeletal muscle insulin sensitivity in subjects with cancer and cachexia.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (11 items).
Location: Pennington Biomedical Research Center — Baton Rouge, Louisiana
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Prior diagnosis of type 2 diabetes
- Prior or current thiazolidinedione (TZD) therapy
- Known hypersensitivity to TZD
- New York Heart Association (NYHA) class I-IV heart failure
- History of or actively treated bladder cancer
- Current use of CYP2C inhibitor (e.g., gemfibrozil) or CYP2C inducer (e.g., rifampin)
- Inadequate hepatic function
- Currently pregnant, breastfeeding, or planning to become pregnant within the next 16 weeks
- Contraindications to magnetic resonance imaging (e.g., implanted cardiac device, cochlear implant)
- Any other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Pennington Biomedical Research Center — Baton Rouge, Louisiana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.