RESISTance Exercise for Depression Trial (NCT06110897)
Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine
🩺 Plain-English Summary (8th-Grade Level)
Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (10 items).
Location: Iowa State University — Ames, Iowa
Age range: 18 Years to 65 Years
🧪 Interventions in This Study
- High Dose Resistance Exercise Training (BEHAVIORAL)
- Low Dose Resistance Exercise Training Group (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Currently pregnant, nursing, or planning to become pregnant during the trial
- Class III+ obesity
- Diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID
- Diagnosed with current Substance Use Disorder, via the SCID
- Active suicidal ideation with specific plan and intent ('5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale), which would necessitate immediate emergent care
- Exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, as assessed by clinical research personnel
- Currently meets resistance exercise recommendations (2 days per week) for the last 8 weeks
- Self-reporting a concussion/traumatic brain injury within the last 3 months
- Having cardiovascular disease, uncontrolled hypertension, or uncontrolled diabetes
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (2 Sites)
- Iowa State University — Ames, Iowa
- University of Wisconsin - Madison — Madison, Wisconsin
📞 Contact the Study Coordinator
Phone: (608) 890-0154
Email: jouzi@wisc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Major Depressive Disorder
- Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study — San Francisco, California
- Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression — Belmont, Massachusetts
- Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents — Birmingham, Alabama
- Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial — Vancouver, British Columbia
- Fisher Wallace Neurostimulation & Depression Study — New York, New York
Explore by condition: All Major Depressive Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.