The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD (NCT06144203)
🩺 Plain-English Summary (8th-Grade Level)
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (26 items).
Location: Wade Hall - University of Alabama — Tuscaloosa, Alabama
Age range: 18 Years to 64 Years
🧪 Interventions in This Study
- Exercise (BEHAVIORAL)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria for all participants:
- current substance use disorder (other than alcohol, nicotine, or cannabis)
- acute suicidality
- history of bipolar/psychotic disorder
- changes to or addition of psychiatric medication in the past 4 weeks (6 weeks for fluoxetine)
- medications that effect neurovascular properties upon which BOLD fMRI capitalizes (e.g., water pills)
- history of neurological disorders or disease (e.g., traumatic brain injury, epilepsy, seizures)
- loss of consciousness \> 10 minutes
- intellectual disabilities (IQ\<70)
- developmental disorders
- MRI contraindication (e.g., internal ferromagnetic objects such as electronic devices, surgical implants, shrapnel; see phone screen)
- claustrophobia or the inability to lie still in a confined space
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Wade Hall - University of Alabama — Tuscaloosa, Alabama
📞 Contact the Study Coordinator
Phone: (205) 348-2684
Email: kmcrombie@ua.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in PTSD
- Improving Therapeutic Learning for PTSD — Austin, Texas
- Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans — Houston, Texas
- Sensory Motor Arousal Regulation Treatment (SMART) Study — London, Ontario
- Circadian Influence on Prolonged Exposure Therapy for PTSD — Boston, Massachusetts
- Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series — Strongsville, Ohio
- Adolescent Stress and Substance Intervention Subsequent to Trauma — Providence, Rhode Island
Explore by condition: All PTSD clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.