Who is eligible for clinical trial NCT06424184?

Participants must meet the protocol's inclusion criteria for Stimulant Use. The stated age range is 18 Years to 65 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT06424184 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-20

Accelerated rTMS for Substance Use Disorder and Depression (NCT06424184)

Substance Use Disorder Treatment With Accelerated Repetitive Transcranial Magnetic Stimulation for Depression (START-D)

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: University of Texas Southwestern Medical Center

🩺 Plain-English Summary (8th-Grade Level)

This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder \[including methamphetamine or cocaine use disorder (MUD/CUD)\].

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (10 items).

Location: UT Southwestern Medical Center — Dallas, Texas

Age range: 18 Years to 65 Years

🧪 Interventions in This Study

Accelerated Repetitive Transcranial Magnetic Stimulation (DEVICE)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Be aged 18-65 years, inclusive.
Be able to sufficiently understand, speak, and read English to provide informed consent and ask relevant questions, and be willing to comply with all study procedure instructions.
Self-report stimulant use (cocaine, methamphetamine, or prescription stimulants) at least 10 days in the 30-day period prior to consent.
Have a diagnosis of moderate or severe Cocaine or Methamphetamine Use Disorder (CUD/MUD) or other Stimulant Use Disorder over the past 12 months (as determined by the MINI International Neuropsychiatric Interview).
Have a PHQ9 of greater than or equal to five (5).
Be willing to provide urine samples, EEGs, and ECGs.
Be willing to use appropriate birth control method during the treatment phase of the study, if individual is of childbearing potential.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Have a current pattern of alcohol, benzodiazepine, or other sedative/hypnotic use that would preclude safe participation in the study, as determined by the PI or their designee.
Have a history of a serious medical disorder that, in the opinion of the PI or their designee, would make it unsafe to participate in the study or may prevent collection of study data (e.g., disabling terminal diagnosis for which hospice care is being sought; serious illness requiring systemic treatment and/or hospitalization until participant either completes therapy and/or is clinically stable on therapy, in the opinion of the PI or their designee, prior to study entry).
Have a documented history of unprovoked seizure (lifetime) or any seizure in the past 6 months.
Have a documented history of brain lesion(s) and/or tumor(s).
Have metal implants or non-removable metal objects above the neck.
Current pregnancy as determined by a urine screening.
Current or lifetime manic or hypomanic episode, defined by MINI diagnostic interview.
Current psychotic disorder.
Are a prisoner or in police custody at the time of eligibility screening.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

UT Southwestern Medical Center — Dallas, Texas

📞 Contact the Study Coordinator

Phone: (214) 998-6504

Email: Taylor.Helmbrecht@UTSouthwestern.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Stimulant Use

Enhancing Prospective Thinking in Early Recovery — Indianapolis, Indiana
Project neuroARTEMIS — Winston-Salem, North Carolina

Explore by condition: All Stimulant Use clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗