A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy (NCT06541704)
A Multicenter, Randomized, Double-Masked, Placebo-Controlled Phase 3 Study of the Efficacy, Safety, and Tolerability of Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
🩺 Plain-English Summary (8th-Grade Level)
This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead). The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) are in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Who can join: Review the eligibility criteria below.
Location: Barnet Dulaney Perkins Eye Center-Ophthamalogy — Chandler, Arizona
Age range: 50 Years to 85 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (224 Sites)
Showing the first 25 of 224 sites.
- Barnet Dulaney Perkins Eye Center-Ophthamalogy — Chandler, Arizona
- Barnet Dulaney Perkins Eye Center — Phoenix, Arizona
- Associated Retina Consultants — Phoenix, Arizona
- Retinal Research Institute — Phoenix, Arizona
- Retina Macula Institute of Arizona — Scottsdale, Arizona
- Retina Associates of Tuscan — Tucson, Arizona
- Retina Partners of Northwest Arkansas, PLLC — Springdale, Arkansas
- Retina Vitreous Associates Medical Group — Beverly Hills, California
- Retina Specialists of Beverly Hills- Department of Ophthalmology — Beverly Hills, California
- The Retina Partners — Encino, California
- Eye Medical Center of Fresno — Fresno, California
- Retina Consultants of Orange County — Fullerton, California
- Salehi Retina Institute dba Retina Associates of Southern California — Huntington Beach, California
- University of California Irvine — Irvine, California
- University of California San Diego, Jacobs Retina Center — La Jolla, California
- South Coast Retina Center — Long Beach, California
- American Institute of Research — Los Angeles, California
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Jules Stein Eye Institute in David Geffen School of Medicine at UCLA — Los Angeles, California
- Retinal Consultants Medical Group Inc Modesto — Modesto, California
- Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California
- California Retina Consultants — Oxnard, California
- Desert Retina Consultants — Palm Desert, California
- California Eye Specialists Medical Group Inc. — Pasadena, California
- Retina Consultants San Diego — Poway, California
📞 Contact the Study Coordinator
Phone: (844) 734-6643
Email: clinicaltrials@regeneron.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.