A Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH Liver Fibrosis (NCT06903065)
A Phase Ib, Multicenter, Open-Label, Single-Arm Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Patients With Advanced MASH Liver Fibrosis
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity and activity of RO7790121 in participants with advanced metabolic dysfunction-associated steatohepatitis (MASH) fibrosis.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (16 items).
Location: Adobe Clinical Research, LLC — Tucson, Arizona
Age range: 18 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Weight gain or loss \>5% in the 3 months prior to baseline or \>10% in the 6 months prior to baseline
- Bariatric surgery within 1 year prior to baseline
- Current signs or prior history of decompensated liver disease
- Complications or clinical evidence of portal hypertension
- Lack of peripheral venous access
- Other causes of liver disease based on medical history and/or centralized review of liver histology
- History of liver transplantation
- Current or prior history of hepatocellular carcinoma (HCC)
- Uncontrolled hypertension
- Concomitant Type 1 diabetes, or Type 2 diabetes with HbA1c \>10%
- History of malignancy within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (15 Sites)
- Adobe Clinical Research, LLC — Tucson, Arizona
- Gastrointestinal Specialists of Georgia, PC — Marietta, Georgia
- Delta Research Partners, LLC (Bastrop) — Bastrop, Louisiana
- Jubilee Clinical Research NV, LLC — Las Vegas, Nevada
- Innovative Clinical Research — Clarksville, Tennessee
- Pinnacle Clinical Research - Austin — Austin, Texas
- Bellaire Clinical Research, LLC — Bellaire, Texas
- Pinnacle Clinical Research Georgetown — Georgetown, Texas
- DHR Health Institute for Research and Development — McAllen, Texas
- Pinnacle Clinical Research, PLLC — San Antonio, Texas
- GI Alliance — Southlake, Texas
- Centro de Investigacion y Gastroenterologia — Mexico City, Mexico CITY (federal District)
- Fundacion Santos Y De La Garza Evia IBP — San Pedro Garza García, Nuevo León
- FDI Clinicial Research - Mayaguez — Mayagez,
- Fundacion de Investigacion de Diego — San Juan,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in MASH
- Study of Resmetirom in Children and Adolescents With MASH — Indianapolis, Indiana
- Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants — Miami, Florida
Explore by condition: All MASH clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.