Who is eligible for clinical trial NCT06942559?

Participants must meet the protocol's inclusion criteria for Obsessive Compulsive Disorder (OCD). The stated age range is 18 Years to 65 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT06942559 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-04-16

Brain-Oscillation Synchronized Stimulation of the DMPFC (NCT06942559)

Brain-Oscillation Synchronized Stimulation of the DMPFC: A Single-Blind Study for Personalized Neuromodulation in OCD

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Centre for Addiction and Mental Health

🩺 Plain-English Summary (8th-Grade Level)

This trial aims to obtain initial evidence about the clinical efficacy and modulation of neurophysiological markers in obsessive compulsive disorder (OCD) using personalized (i.e., electroencephalography (EEG)-triggered) repetitive transcranial magnetic stimulation (rTMS) as compared to non-personalized (i.e., non-EEG triggered), standard rTMS applied to the dorsomedial prefrontal cortex.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (10 items).

Location: Centre for Addiction and Mental Health — Toronto, Ontario

Age range: 18 Years to 65 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Are 18-65 years old;
Have OCD as a primary disorder, confirmed by a Mini-International Neuropsychiatric Interview (MINI) diagnosis of OCD, with treatment resistance defined as a failure of at least one course of cognitive-behavioural therapy or a single trial of an SSRI;
Does not meet criteria for substance use disorder as determined by the MINI (with the exception of nicotine and caffeine);
Have a Y-BOCS score \>20;
Are fluent in the English language (spoken, written, reading);
Have had no increase or initiation of any psychotropic medication in the 4 weeks prior to screening;
Must be deemed to have capacity to provide informed consent;
Must sign and date the informed consent form;
Stated willingness to comply with all study procedures.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Have any contraindications to TMS as determined by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS) questionnaire;
Have a history of a medical or neurological disorder that affects the central nervous system (e.g., traumatic brain injury, stroke, Parkinson's disease);
Are pregnant or breast feeding. TMS is not unsafe in pregnancy and therefore the study team is not requiring a pregnancy test prior to entry. If participants become pregnant during the study they will not be excluded. The study team is not including people who are currently aware of being pregnant as OCD can be affected during the later stages of pregnancy and therefore is a potential confound;
Have a history of seizures;
Have any metal implants or dentures;
Have a serious or unstable medical condition requiring immediate investigation or treatment (e.g., severe or recent cardiac disease);
Have a cardiac pacemaker, cochlear implants, implanted electronic devices, non-electronic metallic implants, or other contraindications for rTMS;
Take more than 2mg of lorazepam or equivalent benzodiazepine, or any anticonvulsant medication;
Fulfill criteria for Alcohol Use Disorder.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Centre for Addiction and Mental Health — Toronto, Ontario

📞 Contact the Study Coordinator

Phone: (416) 535-8501

Email: brigitte.zrenner@camh.ca

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Obsessive Compulsive Disorder (OCD)

Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder — New York, New York
ERP to Improve Functioning in Veterans With OCD — East Orange, New Jersey
Neurophysiological Investigation of the Approach-avoidance Axis in OCD: Applications to Neuromodulation — Houston, Texas
Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder — New Haven, Connecticut
Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD — Houston, Texas

Explore by condition: All Obsessive Compulsive Disorder (OCD) clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗