Who is eligible for clinical trial NCT06973785?

Participants must meet the protocol's inclusion criteria for ACL - Anterior Cruciate Ligament Rupture. The stated age range is 15 Years to 55 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT06973785 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-20

Non-Narcotic Pain Control After ACL Reconstruction (NCT06973785)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: The Cleveland Clinic

🩺 Plain-English Summary (8th-Grade Level)

This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses taken and documenting the number of patients with no exposure to any narcotics (take zero oxycodone) after undergoing primary knee ACL reconstruction outpatient surgery.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (1 items).

Location: Cleveland Clinic Coral Springs — Coral Springs, Florida

Age range: 15 Years to 55 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged 15-55 years
Primary Autograft ACL surgery
Ability to take oral medication and willingness to patriciate in a virtual 1 week follow-up pill count visit

Usually NOT eligible if any of the following apply:

Exclusion Criteria: 1\. Any extensor mechanism dislocation or disruption 2. Multi-ligament injury that requires repair 3. Treatment with another investigational drug or other intervention concurrently or previously that would interfere with postoperative pain control 4. Psychiatric illness that impedes evaluation of pain and/or narcotics use 5. History of Chronic Kidney Disease 6. History of inflammatory arthritis, diabetes, or autoimmune disease 7. History of GI bleed or documented GI ulcer (diagnosed by endoscopy) 8. Allograft or revision of ACLR 9. Contraindications to ketorolac or opioids \-

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (3 Sites)

Cleveland Clinic Coral Springs — Coral Springs, Florida
Cleveland clinic sports medicine — Garfield, Ohio
Cleveland Clinic — Strongsville, Ohio

📞 Contact the Study Coordinator

Phone: (866) 223-8100

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in ACL - Anterior Cruciate Ligament Rupture

Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings — Hamilton, Ontario

Explore by condition: All ACL - Anterior Cruciate Ligament Rupture clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗