Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder (NCT07214467)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to determine if personalized (adaptive) Deep Brain Stimulation (DBS) based upon invasive brain mapping is safe and can lead to better outcomes like reductions in craving and opioid use.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (16 items).
Location: University of California, San Francisco — San Francisco, California
Age range: 22 Years to 75 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Pregnancy or lactation.
- Non-English speaking.
- Participants are not willing to start MOUD treatment with buprenorphine or to switch MOUD to buprenorphine if they are already on other MOUD, for the duration of the study.
- OUD treatment with another investigational drug or other intervention within 3 months.
- History of primary psychosis or Bipolar I disorder per the medical interview.
- History of severe personality disorder that could interfere with study participation (e.g., antisocial personality disorder) per the medical interview.
- History of traumatic brain injury with loss of consciousness greater than 5 minutes.
- Clinically significant cognitive impairment per neuropsychological testing.
- History of suicidal attempts in the past 3 years or current suicidal thoughts per psychiatric evaluation.
- Coagulopathy: INR \> 1.4, aPTT \> 40 s, platelets \< 100,000.
- Current clinically significant medical or neurologic disease that affects brain function (e.g., recent stroke, myocardial infarction, seizures not due to alcohol withdrawal).
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- University of California, San Francisco — San Francisco, California
📞 Contact the Study Coordinator
Phone: (415) 514-6551
Email: TN2Lab@ucsf.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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Explore by condition: All Substance Use Disorder (SUD) clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.