The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (NCT07224711)
The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (IMPALA ERAS)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major non-cardiac surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (11 items).
Location: Vanderbilt University Medical Center — Nashville, Tennessee
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion criteria:
- ASA class \>IV
- Emergent procedures
- Allergy or any contraindication to lidocaine infusion
- Patient refusal
- Unable to receive or refusal to receive a regional nerve block
- Patients who receive an epidural due to standard of care
- Direct transfer from operating room to ICU with endotracheal tube in place
- Treating team determines patient ineligible prior to study drug administration
- Same day surgery
- Pregnancy (all female patient of child-bearing age will undergo a pregnancy test the day of surgery)
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Vanderbilt University Medical Center — Nashville, Tennessee
📞 Contact the Study Coordinator
Phone: (615) 936-3198
Email: danial.shams@vumc.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Pain
- AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT) — Los Angeles, California
- Neuromodulation as a Treatment for Chemotherapy-Induced Peripheral Neuropathy — Houston, Texas
- Strength and Pain-Coping Through Resilience and Knowledge — Baltimore, Maryland
- Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery — New Haven, Connecticut
- Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE) — Toronto, Ontario
Explore by condition: All Pain clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.