A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment (NCT07293247)
Involved-Station, Intensity-Modulated Post-Operative Radiation Therapy (I²-PORT) for Resected Non-Small Cell Lung Cancer With Residual Mediastinal Adenopathy After Neoadjuvant Therapy (ypN2)
🩺 Plain-English Summary (8th-Grade Level)
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients with non-small cell lung cancer (NSCLC) who have remaining lymph node cancer after surgery. Radiation therapy uses high-energy X-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Intensity-modulated radiation therapy is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Adding I²-PORT radiation therapy to standard therapy may be more effective than standard therapy alone in reducing the risk of cancer returning in those who have undergone surgery for NSCLC.
Who can join: Review the eligibility criteria below.
Location: NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (74 Sites)
Showing the first 25 of 74 sites.
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas
- USC / Norris Comprehensive Cancer Center — Los Angeles, California
- OSF Saint Joseph Medical Center — Bloomington, Illinois
- Illinois CancerCare-Bloomington — Bloomington, Illinois
- Illinois CancerCare-Canton — Canton, Illinois
- Illinois CancerCare-Carthage — Carthage, Illinois
- Rush MD Anderson Cancer Center — Chicago, Illinois
- Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois
- Decatur Memorial Hospital — Decatur, Illinois
- Illinois CancerCare-Eureka — Eureka, Illinois
- Illinois CancerCare-Galesburg — Galesburg, Illinois
- Illinois CancerCare-Kewanee Clinic — Kewanee, Illinois
- Illinois CancerCare-Macomb — Macomb, Illinois
- Cancer Care Center of O'Fallon — O'Fallon, Illinois
- HSHS Saint Elizabeth's Hospital — O'Fallon, Illinois
- Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois
- Illinois CancerCare-Pekin — Pekin, Illinois
- OSF Saint Francis Radiation Oncology at Pekin — Pekin, Illinois
- Illinois CancerCare-Peoria — Peoria, Illinois
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center — Peoria, Illinois
- OSF Saint Francis Medical Center — Peoria, Illinois
- Illinois CancerCare-Peru — Peru, Illinois
- Illinois CancerCare-Princeton — Princeton, Illinois
- Illinois CancerCare - Washington — Washington, Illinois
- MaineHealth Coastal Cancer Treatment Center — Bath, Maine
📞 Contact the Study Coordinator
Phone: (773) 702-9171
Email: lungprotocols@alliancenctn.org
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.