Who is eligible for clinical trial NCT07679607?

Participants must meet the protocol's inclusion criteria for Lung Cancer (NSCLC). The stated age range is 18 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT07679607 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-06-29

GCC 2545- Improving Post-Radiotherapy Respiratory Function Through Sparing Serial and Parallel Components in the Lung (NCT07679607)

🟡 Not Yet Recruiting Phase2 📋 Clinical Research Protocol Sponsor: University of Maryland, Baltimore

🩺 Plain-English Summary (8th-Grade Level)

Decreased respiratory function is a common side effect experienced by non-small cell lung cancer (NSCLC) patients who receive radiation therapy. In current clinical practice when treating cancerous lesions in the lung, it is not standard to explicitly try and avoid excessive radiation dose and therefore radiation injury to smaller airways. However, because of this patients may obtain damage to an airway segment can cause downstream regions in the lung to lose their "supply line" and, therefore, cause patients to lose the ability to exchange oxygen with the blood. The purpose of this clinical trial is to systematically compare post-treatment lung function of those who receive regular clinical radiation therapy (standard of care \[SoC\]) versus those who receive the airway-sparing radiation therapy regimen. The investigators hope to show that, by preserving airways and connected lung regions, participants will be able to retain a larger amount of their lung function, which will have a direct, positive impact on their post-treatment quality of life.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (7 items).

Location: University of Maryland Greenebaum Cancer Center — Baltimore, Maryland

Age range: 18 Years

🧪 Interventions in This Study

SOC Radiation Treatment Planning (RADIATION)
INSPIRE Radiation Treatment Planning (RADIATION)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Step 1- Inclusion Criteria
Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage III NSCLC per AJCC ver 9
Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemothrapy, immunotherapy).
No restrictions on number radiotherapy fractions, or location/number of lesions
ECOG performance status ≤ 3
Ability to hold breath for ≥ 15 seconds
Patient has signed informed consent document and agreed to study procedures Step 2- Inclusion Criteria 1. Patient has completed 4DCT and BHCT with subsequent plans created and Radiation Oncologist has determined that patient would benefit from INSPIRE RT.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Step 1- Exclusion Criteria
Prior lung cancer-directed radiotherapy
Recent (\< 12 mo) or planned lung surgery (which would confound pre- and post-RT lung function measures)
Patients with metal implants or metal stents in the thoracic region
Known severe chronic obstructive pulmonary disease or interstitial lung disease
Women who are pregnant or trying to get pregnant Step 2- Exclusion Criteria 1\. Patient found to not benefit from INSPIRE RT after comparison of treatment plans.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of Maryland Greenebaum Cancer Center — Baltimore, Maryland

📞 Contact the Study Coordinator

Phone: (410) 328-6080

Email: asawant@som.umaryland.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗