🏛️ Verified NIH Record • Updated 2026-08-21

Genetic of Skeletal Muscle Insulin Resistance (NCT07780513)

Identification of Cell Type-Specific Insulin Responsive Quantitative Trait Loci (QTL) in Human Skeletal Muscle

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: The University of Texas Health Science Center at San Antonio

🩺 Plain-English Summary (8th-Grade Level)

In this study, the investigators will use euglycemic/hyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus ribonucleic acid sequencing (RNA-Seq) and assay for transposase-accessible chromatin using sequencing (ATAC- seq) to reveal cell type-specific molecular response quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (18 items).

Location: Texas Diabetes Institute - University Health System, San Antonio, Texas 78207 — San Antonio, Texas

Age range: 18 Years to 75 Years

🧪 Interventions in This Study

  • Insulin 80mU/m2*min (OTHER)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Urine albumin excretion\>300mg/day
  • Partial thromboplastin time (PTT) \>35International normalized ratio (INR) \> 1.2
  • No oral corticosteroids for 1 month
  • No Sodium-glucose co-transporter 2 (SGLT2) inhibitor for 3 months
  • No glucagon-like peptide-1 (GLP-1) receptor agonist for 6 months
  • Any anti-platelet or anti-coagulation medication other than as needed for Pain Management
  • No alcohol 4 days before the insulin clamp and biopsy procedure
  • No acute structural knee injuries
  • No Rheumatologic muscular or nervous system disease
  • Pregnancy, Intentions to become pregnant, or Breastfeeding
  • Blood Pressure \>170/110

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

  • Texas Diabetes Institute - University Health System, San Antonio, Texas 78207 — San Antonio, Texas

📞 Contact the Study Coordinator

Phone: (210) 567-0739

Email: nortonl@uthscsa.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
  • 💵 Compensation indicated: All participants will receive an infusion of \[3-3H\]glucose.

Explore by condition: All Insulin Stimulated clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗