39 Paid Clinical Research Studies in Lexington, Kentucky

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

This study will test the effectiveness, implementation outcomes, and cost effectiveness of a locally-tailored, health kiosk to reduce overdose, hepatitis C, and HIV risk behavior a

📍 University of Kentucky — Lexington, Kentucky

Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLs

This is a multicenter, open-label, single-arm study to evaluate the safety and dosimetry of Lutathera in adolescent patients 12 to \<18 years old with somatostatin receptor positiv

📍 University of Kentucky — Lexington, Kentucky

💵 Each patient will receive a total of 4 doses of Lutathera (7.4 GBq/200 mCi x 4 administrations every 8 weeks; cumulative

Effectiveness of a Multi-Level Smoking Cessation Program for High-Risk Women in Rural Communities

This phase IV trial examines the effectiveness of a multi-level smoking cessation program for high-risk women in rural communities. Cigarette smoking is a major risk factor for cer

📍 University of Kentucky/Markey Cancer Center — Lexington, Kentucky

Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers

Patients will receive standard of care radiation therapy to the primary tumor of the head and neck and involved nodal metastasis and draining nodal basin and either weekly cisplati

📍 University of Kentucky — Lexington, Kentucky

💵 Patients will receive standard of care radiation therapy to the primary tumor of the head and neck and involved nodal me

I Vaccinate: Testing Multi-Level Interventions to Improve HPV Vaccination

This trial studies how well a multi-level health system-based intervention works in improving human papillomavirus (HPV) vaccine initiation and completion among children in health

📍 University of Kentucky/Markey Cancer Center — Lexington, Kentucky

Feasibility, Acceptability, and Preliminary Efficacy of an HIV Prevention Intervention for Older Black Women

The goal of this clinical trial is to learn whether a group-based HIV prevention program can improve HIV knowledge, prevention behaviors, and testing in older Black women aged 50 a

📍 University of Kentucky — Lexington, Kentucky

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.

📍 University of Kentucky — Lexington, Kentucky

Endodontic Microsurgery

Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been mor

📍 University of Kentucky College of Dentistry Endodontics Division — Lexington, Kentucky

💵 In this study patients will receive endodontic microsurgery with one group having the osteotomy filled with PRF prior to

Biomarkers in Management of Post Partum Preeclampsia

Participants are recruited for a research study about how lab values change following delivery in people with Preeclampsia with Severe Features. Preeclampsia with Severe Features m

📍 University of Kentucky — Lexington, Kentucky

💵 Patients will receive standard postpartum outpatient follow-up.

Integrative Alcohol and Risky Sex Feedback for College Students

Alcohol misuse and related risky sexual behaviors are significant health concerns for college students. Two-thirds of students are current drinkers, at least 1 in 3 report past mon

📍 University of Kentucky — Lexington, Kentucky

MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity. The main question\[s\] it aims to a

📍 University of Kentucky — Lexington, Kentucky

💵 Participants will receive either dental cleaning and oral hygiene instruction or oral hygiene instruction alone.

Oral Mucosa Wound Healing After Gingival Recession Treatment in Diabetic Patients. A Clinical Study.

The goal of this clinical trial is to evaluate local and systemic factors involved in oral mucosal healing after gingival recession treatment in diabetic patients and to compare th

📍 College of Dentistry - University of Kentucky — Lexington, Kentucky

Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial

The goal of this clinical trial is to evaluate local and systemic factors involved in palatal mucosal healing after Free Gingival Graft harvest in diabetic patients and to compare

📍 College of Dentistry - University of Kentucky — Lexington, Kentucky

Parents' HPV Stories

The goal of this clinical trial is to evaluate the feasibility of intervention implementation in two clinics in rural KY, and its preliminary efficacy with regards to increasing va

📍 University of Kentucky — Lexington, Kentucky

Training Induced Muscle-Adipose EV Communication

This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise. These vesicles carry important molecules t

📍 University of Kentucky — Lexington, Kentucky

Tasting Plant Forward Meals

This study aims to examine how the amount of potato and form of potato within a meal impacts intake and acceptability of other non-starchy vegetables.

📍 University of Kentucky — Lexington, Kentucky

FIT Exercise in 30d of ULLS-induced Muscle Disuse

This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (H

📍 University of Kentucky — Lexington, Kentucky

School Screening and Telemedicine Specialty Referral to Address Childhood Hearing Loss in Rural Kentucky

This trial will evaluate a multilevel intervention (STAR model) that combines mobile health (mHealth) hearing screening tools with telemedicine technology for specialty care access

📍 University of Kentucky — Lexington, Kentucky

Mechanisms for Activation of Beige Adipose Tissue in Humans

Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose to

📍 University of Kentucky — Lexington, Kentucky

Impact of Daily Oral Cannabis Doses in Patients With Cancer

This study will enroll patients with cancer and participants will be randomized to receive one dose of cannabis for approximately 4 months. There is a 3/4 (or 75%) chance that a pa

📍 University of Kentucky — Lexington, Kentucky

💵 There is a 3/4 (or 75%) chance that a participant will receive an active cannabis dose in the study.

Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

This phase I double-blind study focuses on the safety and feasibility of implanting autologous peripheral nerve tissue (PNT) into the substantia nigra area of the brain in persons

📍 University of Kentucky — Lexington, Kentucky

💵 The LEAP trial is a study where the first participant will receive an implantation of the cells from their own sural ner

Leveraging Community-clinical Linkages to Address Unmet Social Needs for People With Diabetes

This study is a hybrid type 2 design to evaluate the effectiveness and implementation of a community-clinical linkage intervention in primary clinics to address unmet social needs

📍 University of Kentucky — Lexington, Kentucky

IOA Preventing Occlusal Changes With MAD Use

This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-re

📍 Orofacial Pain Center - University of Kentucky - Kentucky Clinic — Lexington, Kentucky

Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation

The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main

📍 University of Kentucky — Lexington, Kentucky

Methadone for Post-operative Spine Surgery

The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes

📍 University of Kentucky — Lexington, Kentucky

💵 Patients will be randomized preoperatively to one of two groups: (both groups will receive additional multimodal pain co

PT150 Drug for Use in Alcohol Use Disorder

The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.

📍 University of Kentucky — Lexington, Kentucky

💵 During this session, participants will receive a single administration of alcohol (0.5 g/kg) mixed with lemon lime soda.

Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies

People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the propo

📍 Jia-Rong Wu — Lexington, Kentucky

Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer

This is a large, prospective, single-arm cohort study of transvaginal ultrasonographic screening for ovarian cancer in intermediate to high-risk women from Kentucky. Detection of o

📍 Markey Cancer Center — Lexington, Kentucky

Neuromodulation to Enhance Motor Function in HSP

Hereditary spastic paraplegia (HSP) is a rare neurological condition that causes stiffness, weakness, and difficulty walking due to damage in the nerves that control movement. This

📍 University of Kentucky — Lexington, Kentucky

💵 In this study, participants will receive tSCS twice a week for 8 weeks.

Circadian Rhythms in Postmenopausal Women

This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vul

📍 University of Kentucky — Lexington, Kentucky

Cocaine and Pentoxifylline (BED IN 47)

This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long

📍 Psychopharmacology of Addiction Laboratory — Lexington, Kentucky

Suvorexant and Alcohol

This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other al

📍 Psychopharmacology of Addiction Laboratory — Lexington, Kentucky

Prospective Evaluation of Pathways for Preterm Birth

This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's wi

📍 University of Kentucky — Lexington, Kentucky

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage

The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs).

📍 University of Kentucky — Lexington, Kentucky

💵 Subjects will receive telavancin 10mg/kg (maximum 1000mg) every 24 hours for 3 consecutive doses.

Cannabis for Obesity Trial

The goal of this study is to determine the initial efficacy of once daily oral cannabis for weight loss in obese individuals.

📍 University of Kentucky — Lexington, Kentucky

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

The investigator hypothesizes that treatment with the ß3 agonist mirabegron results in improved glucose metabolism, including a reversal of prediabetes in obese, insulin-resistant

📍 University of Kentucky — Lexington, Kentucky

Creating VIP Corps to Reduce Maternal Deaths

The goal of this observational study is to create and rigorously evaluate a violence intervention and prevention corps (VIP Corps) training using a randomized controlled trial amon

📍 University of Kentucky — Lexington, Kentucky

Cannabis and Opioid Use Disorder

This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related ou

📍 Center on Drug and Alcohol Research — Lexington, Kentucky

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

In this Phase 2 study, we will conduct an efficacy and safety study of the combination of investigational drug BMX-001, with short-course radiotherapy (SCRT) or long-course chemora

📍 Markey Cancer Center — Lexington, Kentucky

💵 Patients will receive 3 cycles of FOLFOX or 2 cycles of CAPOX and then be assigned to SCRT or LCCRT prior to randomizati