Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study (NCT03442101)
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study in Medication-naïve First Episode Psychosis Patients
🩺 Plain-English Summary (8th-Grade Level)
Psychosis is a heterogeneous disorder and present treatment only works for a limited number of patients. In order to identify new therapeutic targets, this study will longitudinally characterize the underlying pathologies in those with poor treatment response using complimentary brain imaging modalities.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (9 items).
Location: Sparks Center — Birmingham, Alabama
Age range: 17 Years to 35 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Inability to sign informed consent assessed by the Evaluation to sign - - Consent form
- Poorly controlled acute or chronic medical and neurological conditions
- History of head trauma with loss of consciousness for \>2 minutes
- Clinically significant depression, hypomania, or mania
- Active substance abuse or dependence (except for nicotine)
- Suspected substance-induced psychosis
- Treatment with drugs known to affect brain glutamate levels
- Pregnant females
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Sparks Center — Birmingham, Alabama
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Psychosis
- Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness — Charlestown, Massachusetts
- Psychosis TMS Study — Charlestown, Massachusetts
- Youth Nominated Support Team — Irvine, California
- Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk — Glen Oaks, New York
- Cognitive Strategies in Early Psychosis 2 — Minneapolis, Minnesota
Explore by condition: All Psychosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.