Who is eligible for clinical trial NCT05646732?

Participants must meet the protocol's inclusion criteria for Post Traumatic Stress Disorder. The stated age range is 18 Years to 55 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT05646732 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2024-04-01

Targeting the Default Mode Network: A TMS-fMRI Study (NCT05646732)

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Allyson Rosen

🩺 Plain-English Summary (8th-Grade Level)

In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this would lead to a personalized approach to rTMS treatment of PTSD based on brain imaging that can be used in a future clinical trial. Participants will be asked to complete psychological testing and questionnaires as well as an initial MRI and two separate TMS-fMRI sessions. Total participation time across all visits is estimated to be five to six hours. Research participation will take place at VA Palo Alto as well as at Stanford University.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (8 items).

Location: VA Palo Alto — Palo Alto, California

Age range: 18 Years to 55 Years

🧪 Interventions in This Study

TMS-fMRI (DEVICE)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Between 18 and 55 years of age
Ability to maintain a Motor Threshold (MT) with single pulse TMS
Ability to safely and comfortably undergo an MRI and TMS
Able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments.
PTSD diagnosis according to the DSM 5, as determined by the Clinician administered PTSD scale (CAPS-5) criteria.
Commitment to maintaining a stable medication regimen between the two fMRI sessions

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Inability to safely and comfortably undergo an MRI. MRI safety will be determined by the center where MRI's are collected.
Inability to safely and comfortably undergo TMS. TMS exclusions include any history or condition that puts patients at risk.
Significant dementia as determined by the Montreal Cognitive Assessments (MoCA)
Common comorbid disorders of Veterans are allowed, but PTSD must be a primary diagnosis causing significant impairment that could not be accounted for by another diagnosis. Medical or mental health conditions that interact with or confound interpretation of PTSD symptoms and anxiety would be exclusionary.
Being in urgent need of care that would make participation impossible
Currently taking medications that increase the risk of seizure or influence hemodynamic response
Presence of any other condition that has the potential to prevent study completion and/or have a confounding effect on the interpretation of results.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

VA Palo Alto — Palo Alto, California

📞 Contact the Study Coordinator

Phone: (650) 493-5000

Email: james.lavacot@va.gov

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗