MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder (NCT05790239)

🧪 Interventions in This Study

• 3,4-methylenedioxymethamphetamine (DRUG)
• d-amphetamine (DRUG)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. At Screening, meet DSM-5 criteria for current PTSD with a symptom duration of at least 6 months.
2. Fluent in speaking and reading the predominantly used or recognized language of the study site (English).
3. Must be a veteran enrolled at a VA Healthcare Center in the Greater Los Angeles area.
4. Able to swallow pills.
5. Agree to have study visits audiovisually recorded, including Experimental Sessions, IR assessments, and non-drug therapy sessions.
6. Able to provide a contact (relative, spouse, close friend, or other support person) who is willing and able to be reached by the investigators in the event of the participant becoming unwell or unreachable.
7. Able to identify appropriate support person(s) to stay with the participant on the evenings of Experimental Sessions if needed.
8. May have well-controlled hypertension that has been successfully treated with anti-hypertensive medicines, if they pass additional screening to rule out underlying cardiovascular disease.
9. May have asymptomatic Hepatitis C virus (HCV) that has previously undergone evaluation and treatment as needed.
10. Body weight of at least 45 kilograms (kg). Participants with a body weight of 45-48 kg must also have a body mass index (BMI) within the range of 18 to 30 kg/m2. BMI must be within 18 to 32 kg/m2 (inclusive).
11. A person able to be pregnant (PABP) must use a highly effective contraceptive method.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

• VA Greater Los Angeles Healthcare System, Westwood campus — Los Angeles, California
• West Los Angeles Veteran Affairs — Los Angeles, California

📞 Contact the Study Coordinator

Phone: (213) 505-1140

Email: Stephanie.Taylor8@va.gov

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Post Traumatic Stress Disorder

• Targeting the Default Mode Network: A TMS-fMRI Study — Palo Alto, California
• Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD — Tallahassee, Florida
• Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD — Toronto, Ontario
• Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD — Minneapolis, Minnesota
• NightWare and Cardiovascular Health in Women With PTSD — Aurora, Colorado

Explore by condition: All Post Traumatic Stress Disorder clinical trials

💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Contact the study coordinator using the phone/email above.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.