Who is eligible for clinical trial NCT06518421?

Participants must meet the protocol's inclusion criteria for Trigeminal Neuralgia. The stated age range is 35 Years to 60 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT06518421 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2024-07-23

Emotion and Memory in Chronic Neuropathic Pain (NCT06518421)

The Role of Limbic Subcortical Structures and Cognition in Chronic Neuropathic Pain

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: University Health Network, Toronto

🩺 Plain-English Summary (8th-Grade Level)

Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain. Abnormalities in brain structures associated with emotion and memory, including the hippocampus and amygdala, can be affected by chronic pain. Understanding the relationship between chronic pain, structural brain changes, and cognitive functioning will lead to improved diagnosis, treatment, and outcomes in chronic pain disorders. In this project, the investigators will use advanced brain imaging techniques that assess the structure and function of the brain along with cognitive assessments to examine the overlap between chronic pain and emotion-memory processes. The study team will conduct the study using an excellent model of chronic pain-trigeminal neuralgia, a severe form of facial pain that responds well to surgical treatment. Brain images and cognitive data will be collected from participants before and after surgical treatment for pain. This information will be analyzed and compared with age- and sex-matched healthy individuals. This study will be the first to thoroughly investigate relationships between brain structure and function, cognition (memory, emotion), and promises to impact our understanding of chronic neuropathic pain conditions.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (6 items).

Location: Toronto Western Hospital — Toronto, Ontario

Age range: 35 Years to 60 Years

🧪 Interventions in This Study

Neuropsychological assessments (BEHAVIORAL)
MR Imaging (DIAGNOSTIC_TEST)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

(for HC and TN):
Age between 35 and 60 years old
Absence of other active major neurological or psychiatric disorders
Absence of MRI contraindications
Able to communicate sufficiently to complete tasks and questionnaires
Montreal Cognitive Assessment (MoCA) score greater than 23/30 (MoCA ≤23/30 could indicate severe cognitive impairment) Inclusion Criteria for TN:
Experiencing TN pain over a period of 6 months
Stable medication use
Meet established diagnostic criteria for TN (ICHD-3)

Usually NOT eligible if any of the following apply:

Exclusion Criteria (both HC and TN):
Presence of other chronic pain/headache conditions
Untreated hypertension or diabetes mellitus
History of chronic drug or substance use disorder, chronic use of opioids or steroids, head trauma affecting cognitive performance,
History/presence of active psychiatric illness and/or current use of psychoactive medication
History of multiple sclerosis, skull base injury or tumours

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Toronto Western Hospital — Toronto, Ontario

📞 Contact the Study Coordinator

Phone: (416) 340-4907

Email: jacob.kim@uhn.ca

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Trigeminal Neuralgia

Trigeminal Evoked Responses to Improve Rhizotomy — Minneapolis, Minnesota
RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia — Sherbrooke,
MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia — Baltimore, Maryland
Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia — Newark, New Jersey
Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion — Sherbrooke, Quebec

Explore by condition: All Trigeminal Neuralgia clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗