🏛️ Verified NIH Record • Updated 2026-03-16
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization (NCT06550024)
🔵 Active, Not Recruiting Observational / Diagnostic 💊 Investigational Drug / Biologic Sponsor: CrannMed
🩺 Plain-English Summary (8th-Grade Level)
An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (15 items).
Location: University of Alabama Medicine — Birmingham, Alabama
Age range: 40 Years to 79 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Severe knee OA (Kellgren-Lawrence grade 4), or
- Current infection of target joint, or
- Life expectancy less than 36 months, or
- Known advanced atherosclerosis as defined by history of lower extremity or pelvis arterial bypass graft, lower extremity or pelvis arterial stent placement or prior history of vascular claudication, or
- Rheumatoid or known serologic diagnosis of autoimmune arthritis, or
- Prior knee replacement surgery in the target knee, or
- Pain score of \>3 NRS on the non-target knee, or
- An acute internal derangement of the target knee, or
- History of uncorrectable coagulopathy, or
- Prior iodinated contrast reaction resulting in anaphylaxis, or
- Active pregnancy as demonstrated by urine or serum β-hCG, or lactating female, or planning pregnancy in the following 12 months, or
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (8 Sites)
- University of Alabama Medicine — Birmingham, Alabama
- Harbor UCLA Medical Center — Torrance, California
- Advanced Vascular Institute — Panama City, Florida
- IR Centers — Raleigh, North Carolina
- IR Centers — Leesburg, Virginia
- Bokhua Memorial Cardiovascular Center — Tbilisi,
- Royal Berkshire NHS Foundation Trust — Reading,
- Nano Medical Clinic — Tashkent, Uzbekistan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.