Who is eligible for clinical trial NCT06592261?

Participants must meet the protocol's inclusion criteria for Insulin Resistance. The stated age range is 18 Years to 65 Years. Confirm all requirements with the study coordinator.

Does clinical trial NCT06592261 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-05-26

Graded Insulin Suppression Test P&F (NCT06592261)

Human Models of Selective Insulin Resistance: Graded Insulin Suppression Test (GIST) Pilot & Feasibility Study

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Columbia University

🩺 Plain-English Summary (8th-Grade Level)

The goal of this study is to learn about how the hormone insulin controls blood sugar in a variety of people. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level. Participants will be asked to come in for a one-day study visit in which they will undergo a "graded insulin suppression test" ("GIST"). The GIST involves intravenous (into the vein) infusions of octreotide, a medication that turns off the body's own production of insulin, as well as replacement of insulin at two different levels (low and high), with or without replacement of glucagon, and glucose (sugar). The study investigators will check blood sugar levels every few minutes during the procedure to determine the effect of the two different insulin levels. This study will evaluate the GIST in both healthy volunteers and those at higher risk for type 2 diabetes.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (93 items).

Location: Columbia University Irving Medical Center — New York, New York

Age range: 18 Years to 65 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Body mass index of 18-25 and 30-45 kg/m2
Able to understand written and spoken English and/or Spanish
Fasting euinsulinemia (fasting serum insulin of 4-10 μU/mL) for reference group or hyperinsulinemia (fasting serum insulin ≥ 13 μU/mL) for hyperinsulinemic group on screening labs
Written informed consent (in English or Spanish) and any locally required authorization (e.g., Health Insurance Portability and Accountability Act) obtained from the participant prior to performing any protocol-related procedures, including screening evaluations.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Unable to provide informed consent in English or Spanish
Unwillingness to use only bedpan or urinal to void or to refrain from non-emergent mobile device use during the GIST
Documented weight loss of ≥ 5% of baseline within the previous 6 months
Systolic blood pressure \< 90 mm Hg or \> 160 mm Hg, and/or
Diastolic blood pressure \< 60 mm Hg or \> 100 mm Hg
Abnormal resting heart rate: \< 60 or ≥ 110 bpm
Sinus brady or tachycardia that has been worked up and considered benign by the recruit's personal physician may be permitted at the PI's discretion
Abnormal screening electrocardiogram (or if on file, performed within previous 90 d):
Non-sinus rhythm
Heart conduction blocks
Previously unknown ischaemic changes that persist on repeat EKG:

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Columbia University Irving Medical Center — New York, New York

📞 Contact the Study Coordinator

Phone: (212) 305-6289

Email: jrc2175@cumc.columbia.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Insulin Resistance

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis — Houston, Texas
Muscle Insulin Resistance in Aging (Mirage) — Orlando, Florida
Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity — Bethesda, Maryland
Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids — Rochester, Minnesota
Alpelisib Challenge Test (ACT) — New York, New York
Human Models of Selective Insulin Resistance: Pancreatic Clamp — New York, New York

Explore by condition: All Insulin Resistance clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Contact the study coordinator using the phone/email above.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗