Sex Differences in Neurobehavioral Response to THC (NCT07225777)
Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder
🩺 Plain-English Summary (8th-Grade Level)
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (8 items).
Location: Medical University of South Carolina — Charleston, South Carolina
Age range: 21 Years to 45 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Lifetime psychotic or bipolar disorder
- Recent drug use other than cannabis
- Current psychotropic medication
- Treatment-seeking for SUD
- Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder)
- Pregnancy/nursing
- MRI contraindications
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Medical University of South Carolina — Charleston, South Carolina
📞 Contact the Study Coordinator
Phone: (843) 876-3528
Email: marterin@musc.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Cannabis Use Disorder
- SV2A Density Cannabis Use Disorder — New Haven, Connecticut
- Cannabidiol and Cannabis Concentrate Users — Aurora, Colorado
- RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative — New York, New York
- A Brief Intervention for Cannabis Use — Charleston, South Carolina
- SCORE Emerging Adult Cannabis Use & Stress — Charleston, South Carolina
- Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder — Toronto, Ontario
Explore by condition: All Cannabis Use Disorder clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.