Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance (NCT07494084)

🧪 Interventions in This Study

• Metyrapone And Hydrocortisone (DRUG)
• Dextrose (DRUG)
• insulin (DRUG)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. Must be between 18-45 years old.
2. Has a BMI of 18-25 kg/m2 stable weight over the previous 6 weeks.
3. Is physically and psychologically healthy (incl. regular menstrual cycles in women, no clinical disorders and/or illnesses). Women will be studied during the follicular phase of their menstrual cycle. Menstrual cycle criteria (using PMID 10941950) 18 to 25 years - Cycle variation ≤9 days 26 to 41 years - Cycle variation ≤7 days 42 to 45 years - Cycle variation ≤9 days
4. No current medical or drug treatment (to include steroids or hormones of any type including contraceptives), as assessed by questionnaire.
5. Has a negative pregnancy test (women), no clinically significant abnormalities in blood and urine, and free of traces of drugs.
6. No history of clinically relevant psychiatric illness.
7. No previous history of drug or alcohol abuse.
8. Not a current smoker.
9. No history of brain injury or of learning disability.
10. No previous adverse reaction to sleep deprivation, jet lag, shift work or any of the drugs to be administered.
11. Not vision or hearing impairment unless corrected back to normal.
12. No endocrine disorder (no abnormal thyroid function tests; no abnormal morning blood cortisol; no primary gonadal disease as indicated by serum LH or FSH concentration \> 10 or \> 15 IU/L, respectively; and no hyperprolactinemia indicated by prolactin \> 25 μg/L).

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

• Sleep and Performance Research Center — Spokane, Washington

📞 Contact the Study Coordinator

Phone: (509) 358-7754

Email: devon.hansen@wsu.edu

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

Explore by condition: All Shift Work Schedule clinical trials

💡 How to Participate

1. Check the checklist above to see if you may qualify.
2. Contact the study coordinator using the phone/email above.
3. Ask about the visit schedule, what is covered at no cost, and any travel support.
4. Confirm with your own doctor before making a decision.